George D Hartman
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Explore the profile of George D Hartman including associated specialties, affiliations and a list of published articles.
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113
Citations
1450
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Recent Articles
1.
Kuduk S, DeRatt L, Stoops B, Shaffer P, Lam A, Espiritu C, et al.
Bioorg Med Chem Lett
. 2022 Jun;
72:128823.
PMID: 35644301
The HBV capsid core protein serves a number of important functions in the viral life cycle enabling chronic HBV infection to persist, and therefore is a promising drug target. Interfering...
2.
Kuduk S, Stoops B, Lam A, Espiritu C, Vogel R, Lau V, et al.
Bioorg Med Chem Lett
. 2021 Sep;
52:128353.
PMID: 34492302
The HBV core protein serves multiple essential functions in the viral life cycle that enable chronic HBV infection to persist, and as such, represents a promising drug target. Modulation of...
3.
Kuduk S, Stoops B, Alexander R, Lam A, Espiritu C, Vogel R, et al.
Bioorg Med Chem Lett
. 2021 Feb;
39:127848.
PMID: 33610748
The HBV core protein is a druggable target of interest due to the multiple essential functions in the HBV life cycle to enable chronic HBV infection. The core protein oligomerizes...
4.
Hartman G, Kuduk S, Espiritu C, Lam A
ACS Med Chem Lett
. 2020 Oct;
11(10):1919-1927.
PMID: 33062174
Herein is reported a novel screening paradigm (450s nder striction) for the identification and optimization of hits as part of a hepatitis B virus (HBV) antiviral discovery program. To closely...
5.
Kuduk S, Lam A, Espiritu C, Vogel R, Lau V, Klumpp K, et al.
Bioorg Med Chem Lett
. 2019 Jun;
29(16):2405-2409.
PMID: 31227344
The HBV core protein has multiple essential functions in the HBV life cycle to enable chronic HBV infection. The core protein oligomerizes to form the viral capsid, and modulation of...
6.
Lam A, Espiritu C, Vogel R, Ren S, Lau V, Kelly M, et al.
Antimicrob Agents Chemother
. 2018 Oct;
63(1).
PMID: 30373799
NVR 3-778 is the first capsid assembly modulator (CAM) that has demonstrated antiviral activity in hepatitis B virus (HBV)-infected patients. NVR 3-778 inhibited the generation of infectious HBV DNA-containing virus...
7.
Beshore D, Di Marco C, Chang R, Greshock T, Ma L, Wittmann M, et al.
ACS Med Chem Lett
. 2018 Jul;
9(7):652-656.
PMID: 30034595
Identification of ligands that selectively activate the M muscarinic signaling pathway has been sought for decades to treat a range of neurological and cognitive disorders. Herein, we describe the optimization...
8.
Lam A, Ren S, Espiritu C, Kelly M, Lau V, Zheng L, et al.
Antimicrob Agents Chemother
. 2017 Jun;
61(8).
PMID: 28559265
The hepatitis B virus (HBV) core protein serves multiple essential functions in the viral life cycle, and antiviral agents that target the core protein are being developed. Capsid assembly modulators...
9.
Wolkenberg S, Nolt M, Bilodeau M, Trotter B, Manley P, Kett N, et al.
Bioorg Med Chem Lett
. 2017 Jan;
27(4):1062-1069.
PMID: 28131713
Selective inhibition of Kv1.5, which underlies the ultra-rapid delayed rectifier current, I, has been pursued as a treatment for atrial fibrillation. Here we describe the discovery of MK-1832, a Kv1.5...
10.
Roecker A, Reger T, Mattern M, Mercer S, Bergman J, Schreier J, et al.
Bioorg Med Chem Lett
. 2014 Sep;
24(20):4884-90.
PMID: 25248679
Orexin receptor antagonists have demonstrated clinical utility for the treatment of insomnia. The majority of clinical efforts to date have focused on the development of dual orexin receptor antagonists (DORAs),...