George D Hartman
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Explore the profile of George D Hartman including associated specialties, affiliations and a list of published articles.
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113
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1450
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Recent Articles
11.
Yang Z, Shu Y, Ma L, Wittmann M, Ray W, Seager M, et al.
ACS Med Chem Lett
. 2014 Jun;
5(5):604-8.
PMID: 24900888
Selective activation of the M1 muscarinic receptor via positive allosteric modulation represents an original approach to treat the cognitive decline in patients with Alzheimer's disease. A series of naphthyl-fused 5-membered...
12.
Kuduk S, Chang R, Greshock T, Ray W, Ma L, Wittmann M, et al.
ACS Med Chem Lett
. 2014 Jun;
3(12):1070-4.
PMID: 24900430
Selective activation of the M1 muscarinic receptor via positive allosteric modulation represents an approach to treat the cognitive decline in patients with Alzheimer's disease. A series of amides were examined...
13.
Harrison S, Mulhearn J, Wolkenberg S, Miller P, OMalley S, Zeng Z, et al.
ACS Med Chem Lett
. 2014 Jun;
2(7):498-502.
PMID: 24900338
5-Fluoro-2-aryloxazolo[5,4-b]pyridines were synthesized and investigated as potential (18)F containing β-amyloid PET ligands. In competition binding assays using human AD brain homogenates, compounds 14b, 16b, and 17b were identified as having...
14.
Yang Z, Schlegel K, Shu Y, Reger T, Cube R, Mattern C, et al.
ACS Med Chem Lett
. 2014 Jun;
1(9):504-9.
PMID: 24900239
A novel phenyl acetamide series of short-acting T-type calcium channel antagonists has been identified and evaluated using in vitro and in vivo assays. Heterocycle substitutions of the 4-position of the...
15.
Garbaccio R, Brnardic E, Fraley M, Hartman G, Hutson P, OBrien J, et al.
ACS Med Chem Lett
. 2014 Jun;
1(8):406-10.
PMID: 24900224
Novel oxazolobenzimidazoles are described as potent and selective positive allosteric modulators of the metabotropic glutamate receptor 2. The discovery of this class and optimization of its physical and pharmacokinetic properties...
16.
Kuduk S, Chang R, Di Marco C, Ray W, Ma L, Wittmann M, et al.
ACS Med Chem Lett
. 2014 Jun;
1(6):263-7.
PMID: 24900206
Positive allosteric modulation of the M1 muscarinic receptor represents an approach to treat the cognitive decline in patients with Alzheimer's disease. Replacement of a quinolone ring system in a quinolone...
17.
Barrow J, Rittle K, Reger T, Yang Z, Bondiskey P, McGaughey G, et al.
ACS Med Chem Lett
. 2014 Jun;
1(2):75-9.
PMID: 24900180
A novel series of quinazolinone T-type calcium channel antagonists have been prepared and evaluated using in vitro and in vivo assays. Optimization of the screening hit 3 by modifications of...
18.
Converso A, Hartingh T, Fraley M, Garbaccio R, Hartman G, Huang S, et al.
Bioorg Med Chem Lett
. 2014 May;
24(12):2737-40.
PMID: 24813734
Elevated plasma homocysteine (Hcy) levels are an independent risk factor for the onset and progression of Alzheimer's disease. Reduction of Hcy to normal levels therefore presents a new approach for...
19.
Kuduk S, Di Marco C, Saffold J, Ray W, Ma L, Wittmann M, et al.
Bioorg Med Chem Lett
. 2014 Feb;
24(5):1417-20.
PMID: 24485781
A series of methoxynaphthalene amides were prepared and evaluated as alternatives to quinolizidinone amide M1 positive allosteric modulators. A methoxy group was optimal for M1 activity and addressed key P-gp...
20.
Nanda K, Henze D, Della Penna K, Desai R, Leitl M, Lemaire W, et al.
Bioorg Med Chem Lett
. 2014 Jan;
24(4):1218-21.
PMID: 24461289
A new series of CB2-selective agonists containing a benzimidazole core is reported. Design, synthesis, SAR and pharmacokinetic data for selected compounds are described.