George-Lucian Moldovan
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Explore the profile of George-Lucian Moldovan including associated specialties, affiliations and a list of published articles.
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4400
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Recent Articles
11.
Wang Y, Kelso A, Karamafrooz A, Chen Y, Chen W, Cheng C, et al.
Cell Rep
. 2023 Mar;
42(4):112296.
PMID: 36961817
The arginine dependency of cancer cells creates metabolic vulnerability. In this study, we examine the impact of arginine availability on DNA replication and genotoxicity resistance. Using DNA combing assays, we...
12.
Wang Y, Kelso A, Karamafrooz A, Chen Y, Chen W, Cheng C, et al.
bioRxiv
. 2023 Feb;
PMID: 36778247
The unique arginine dependencies of cancer cell proliferation and survival creates metabolic vulnerability. Here, we investigate the impact of extracellular arginine availability on DNA replication and genotoxic resistance. Using DNA...
13.
Jackson L, Moldovan G
NAR Cancer
. 2022 Dec;
4(4):zcac042.
PMID: 36568963
The discovery of synthetic lethality as a result of the combined loss of PARP1 and BRCA has revolutionized the treatment of DNA repair-deficient cancers. With the development of PARP inhibitors,...
14.
Khatib J, Schleicher E, Jackson L, Dhoonmoon A, Moldovan G, Nicolae C
Oncotarget
. 2022 Oct;
13:1078-1091.
PMID: 36187556
PARP10 is a mono-ADP-ribosyltransferase with multiple cellular functions, including proliferation, apoptosis, metabolism and DNA repair. PARP10 is overexpressed in a significant proportion of tumors, particularly breast and ovarian cancers. Identifying...
15.
Thakar T, Dhoonmoon A, Straka J, Schleicher E, Nicolae C, Moldovan G
Nat Commun
. 2022 Sep;
13(1):5323.
PMID: 36085347
The inability to protect stalled replication forks from nucleolytic degradation drives genome instability and underlies chemosensitivity in BRCA-deficient tumors. An emerging hallmark of BRCA-deficiency is the inability to suppress replication-associated...
16.
Dhoonmoon A, Nicolae C, Moldovan G
Nat Commun
. 2022 Aug;
13(1):5063.
PMID: 36030235
Suppression of nascent DNA degradation has emerged as an essential role of the BRCA pathway in genome protection. In BRCA-deficient cells, the MRE11 nuclease is responsible for both resection of...
17.
Schleicher E, Dhoonmoon A, Jackson L, Khatib J, Nicolae C, Moldovan G
Oncogenesis
. 2022 Jun;
11(1):33.
PMID: 35717336
Maintenance of replication fork stability is essential for genome preservation. Stalled replication forks can be reversed by translocases such as SMARCAL1, and unless protected through the activity of the BRCA...
18.
Hirschler-Laszkiewicz I, Festa F, Huang S, Moldovan G, Nicolae C, Dhoonmoon A, et al.
Sci Rep
. 2022 Apr;
12(1):6311.
PMID: 35428820
Transient receptor potential channel melastatin 2 (TRPM2) is highly expressed in cancer and has an essential function in preserving viability through maintenance of mitochondrial function and antioxidant response. Here, the...
19.
Abu-Libdeh B, Jhujh S, Dhar S, Sommers J, Datta A, Longo G, et al.
J Clin Invest
. 2022 Jan;
132(5).
PMID: 35025765
Despite being the first homolog of the bacterial RecQ helicase to be identified in humans, the function of RECQL1 remains poorly characterized. Furthermore, unlike other members of the human RECQ...
20.
Jackson L, Dhoonmoon A, Hale A, Dennis K, Schleicher E, Nicolae C, et al.
Nucleic Acids Res
. 2021 Dec;
49(22):12855-12869.
PMID: 34871431
Understanding chemoresistance mechanisms in BRCA-deficient cells will allow for identification of biomarkers for predicting tumor response to therapy, as well as the design of novel therapeutic approaches targeting this chemoresistance....