George-Lucian Moldovan
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Explore the profile of George-Lucian Moldovan including associated specialties, affiliations and a list of published articles.
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65
Citations
4400
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Recent Articles
21.
Datta A, Biswas K, Sommers J, Thompson H, Awate S, Nicolae C, et al.
Nat Commun
. 2021 Nov;
12(1):6561.
PMID: 34772932
The tumor suppressor BRCA2 protects stalled forks from degradation to maintain genome stability. However, the molecular mechanism(s) whereby unprotected forks are stabilized remains to be fully characterized. Here, we demonstrate...
22.
Schleicher E, Moldovan G
FEBS J
. 2021 Oct;
289(24):7854-7868.
PMID: 34601817
DNA repair pathways are heavily studied for their role in cancer initiation and progression. Due to the large amount of inherent DNA damage in cancer cells, tumor cells profoundly rely...
23.
Luscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, et al.
FEBS J
. 2021 Jul;
289(23):7399-7410.
PMID: 34323016
ADP-ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad functions, including roles in stress responses elicited, for example, by DNA damage and viral infection and is involved in...
24.
OConnor M, Thakar T, Nicolae C, Moldovan G
Oncogene
. 2021 Jun;
40(30):4872-4883.
PMID: 34158578
Cyclin D1 is an essential regulator of the G1-S cell-cycle transition and is overexpressed in many cancers. Expression of cyclin D1 is under tight cellular regulation that is controlled by...
25.
Weissenrieder J, Reed J, Moldovan G, Johnson M, Trebak M, Neighbors J, et al.
Pharmacol Res Perspect
. 2021 May;
9(3):e00689.
PMID: 34003586
Dopamine D -like receptor antagonists have been suggested as being potential anticancer therapeutics with specific utility for central nervous system cancers due to their ability to cross the blood-brain barrier....
26.
Thakar T, Moldovan G
Nucleic Acids Res
. 2021 May;
49(13):7224-7238.
PMID: 33978751
A universal response to replication stress is replication fork reversal, where the nascent complementary DNA strands are annealed to form a protective four-way junction allowing forks to avert DNA damage...
27.
Clements K, Schleicher E, Thakar T, Hale A, Dhoonmoon A, Tolman N, et al.
Nat Commun
. 2020 Dec;
11(1):6118.
PMID: 33257658
Inhibitors of poly-ADP-ribose polymerase 1 (PARPi) are highly effective in killing cells deficient in homologous recombination (HR); thus, PARPi have been clinically utilized to successfully treat BRCA2-mutant tumors. However, positive...
28.
Schleicher E, Dhoonmoon A, Jackson L, Clements K, Stump C, Nicolae C, et al.
PLoS Genet
. 2020 Nov;
16(11):e1009176.
PMID: 33137164
The ataxia telangiectasia and Rad3-related (ATR) protein kinase is a key regulator of the cellular response to DNA damage. Due to increased amount of replication stress, cancer cells heavily rely...
29.
Awate S, Sommers J, Datta A, Nayak S, Bellani M, Yang O, et al.
Nucleic Acids Res
. 2020 Aug;
48(16):9161-9180.
PMID: 32797166
FANCJ, a DNA helicase and interacting partner of the tumor suppressor BRCA1, is crucial for the repair of DNA interstrand crosslinks (ICL), a highly toxic lesion that leads to chromosomal...
30.
Dhoonmoon A, Schleicher E, Clements K, Nicolae C, Moldovan G
Nucleic Acids Res
. 2020 Jun;
48(13):7252-7264.
PMID: 32542389
The DNA damage response is essential to maintain genomic stability, suppress replication stress, and protect against carcinogenesis. The ATR-CHK1 pathway is an essential component of this response, which regulates cell...