G Sebastiaan Winkler
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Explore the profile of G Sebastiaan Winkler including associated specialties, affiliations and a list of published articles.
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31
Citations
1389
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Recent Articles
1.
Chalabi Hagkarim N, Hajkarim M, Suzuki T, Fujiwara T, Winkler G, Stewart G, et al.
Cells
. 2023 Jul;
12(14).
PMID: 37508532
The mammalian Ccr4-Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene...
2.
Structural and binding characterization of the LacdiNAc-specific adhesin (LabA; HopD) exodomain from
Paraskevopoulou V, Schimpl M, Overman R, Stolnik S, Chen Y, Nguyen L, et al.
Curr Res Struct Biol
. 2021 Jul;
3:19-29.
PMID: 34235483
() uses several outer membrane proteins for adhering to its host's gastric mucosa, an important step in establishing and preserving colonization. Several adhesins (SabA, BabA, HopQ) have been characterized in...
3.
Paraskevopoulou V, Artiaga V, Rowlinson R, Winkler G, Gellert P, Stolnik S, et al.
Protein Expr Purif
. 2019 Jul;
163:105446.
PMID: 31271862
Helicobacter pylori is a pathogenic microorganism infecting approximately 50% of the global population, and establishes life-long colonization despite the hostile stomach environment. H. pylori employs a wide range of outer...
4.
De Matteis C, Randall M, Harvey E, Morris A, Winkler G, Boardman H
Am J Pharm Educ
. 2019 Mar;
83(1):6508.
PMID: 30894766
To design an integrated dyspepsia module for first year pharmacy students that combines clinical and professional practice with fundamental sciences in five different science subject areas. The approaches used in...
5.
Hage N, Howard T, Phillips C, Brassington C, Overman R, Debreczeni J, et al.
Sci Adv
. 2015 Nov;
1(7):e1500315.
PMID: 26601230
Helicobacter pylori is a leading cause of peptic ulceration and gastric cancer worldwide. To achieve colonization of the stomach, this Gram-negative bacterium adheres to Lewis(b) (Le(b)) antigens in the gastric...
6.
Cano F, Rapiteanu R, Winkler G, Lehner P
Nat Commun
. 2015 Oct;
6:8670.
PMID: 26471122
The regulation of protein and mRNA turnover is essential for many cellular processes. We recently showed that ubiquitin--traditionally linked to protein degradation--directly regulates the degradation of mRNAs through the action...
7.
Loczenski Rose V, Shubber S, Sajeesh S, Spain S, Puri S, Allen S, et al.
Biomacromolecules
. 2015 Sep;
16(11):3480-90.
PMID: 26397811
Synthetic polymers containing quaternary phosphonium salts are an emerging class of materials for the delivery of oligo/polynucleotides. In this work, cationic phosphonium salt-containing polymethacrylates and their corresponding ammonium analogues were...
8.
Jadhav G, Kaur I, Maryati M, Airhihen B, Fischer P, Winkler G
Bioorg Med Chem Lett
. 2015 Aug;
25(19):4219-24.
PMID: 26299350
Eukaryotic mRNA contains a 3' poly(A) tail, which plays important roles in the regulation of mRNA stability and translation. Well-characterized enzymes involved in the shortening of the poly(A) tail include...
9.
Maryati M, Airhihen B, Winkler G
Biochem J
. 2015 May;
469(1):169-76.
PMID: 25944446
In eukaryotic cells, the shortening and removal of the poly(A) tail (deadenylation) of cytoplasmic mRNA is a key event in regulated mRNA degradation. A major enzyme involved in deadenylation is...
10.
Hage N, Renshaw J, Winkler G, Gellert P, Stolnik S, Falcone F
Protein Expr Purif
. 2014 Dec;
106:25-30.
PMID: 25448827
Helicobacter pylori is a pathogenic bacterium that has the remarkable ability to withstand the harsh conditions of the stomach for decades. This is achieved through unique evolutionary adaptations, which include...