H Th Marc Timmers
Overview
Explore the profile of H Th Marc Timmers including associated specialties, affiliations and a list of published articles.
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Articles
62
Citations
2422
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0
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Recent Articles
1.
Schroder C, Zissel L, Mersiowsky S, Tekman M, Probst S, Schule K, et al.
Dev Cell
. 2024 Dec;
60(5):735-748.e5.
PMID: 39662466
Mammalian pluripotent cells first segregate into neuroectoderm (NE), or mesoderm and endoderm (ME), characterized by lineage-specific transcriptional programs and chromatin states. To date, the relationship between transcription factor activities and...
2.
Camacho-Ordonez N, Ballestar E, Timmers H, Grimbacher B
J Allergy Clin Immunol
. 2021 Feb;
147(5):1602-1618.
PMID: 33609625
The epigenome is at the interface between environmental factors and the genome, regulating gene transcription, DNA repair, and replication. Epigenetic modifications play a crucial role in establishing and maintaining cell...
3.
Timmers H
Biochim Biophys Acta Gene Regul Mech
. 2020 Jul;
1864(2):194604.
PMID: 32673655
Transcription initiation constitutes a major checkpoint in gene regulation across all living organisms. Control of chromatin function is tightly linked to this checkpoint, which is best illustrated by the SAGA...
4.
Capponi S, Stoffler N, Irimia M, Van Schaik F, Ondik M, Biniossek M, et al.
RNA Biol
. 2019 Sep;
17(1):62-74.
PMID: 31559909
Neuronal microexons represent the most highly conserved class of alternative splicing events and their timed expression shapes neuronal biology, including neuronal commitment and differentiation. The six-nt microexon 34' is included...
5.
Bhuiyan T, Timmers H
Trends Cell Biol
. 2019 Jul;
29(9):752-763.
PMID: 31300188
Basal transcription factor TFIID connects transcription activation to the assembly of the RNA polymerase II preinitiation complex at the core promoter of genes. The mechanistic understanding of TFIID function and...
6.
Timmers H, Tora L
Mol Cell
. 2018 Oct;
72(1):10-17.
PMID: 30290147
Transcript buffering involves reciprocal adjustments between overall rates in mRNA synthesis and degradation to maintain similar cellular concentrations of mRNAs. This phenomenon was first discovered in yeast and encompasses coordination...
7.
Baas R, van Teeffelen H, Tjalsma S, Timmers H
Transcription
. 2017 Oct;
9(2):67-74.
PMID: 28976802
Sma and Mad related (SMAD)-mediated Transforming Growth Factor β (TGF-β) and Bone Morphogenetic Protein (BMP) signaling is required for various cellular processes. The activated heterotrimeric SMAD protein complexes associate with...
8.
Conemans E, Brosens L, Raicu-Ionita G, Pieterman C, de Herder W, Dekkers O, et al.
Pancreatology
. 2017 Aug;
17(5):766-772.
PMID: 28811081
Background: The prognostic value of WHO grade in pancreatic neuroendocrine tumors (PanNETs) in patients with Multiple Endocrine Neoplasia Type 1 (MEN1) is unknown. Methods: We performed a cohort study using...
9.
Baas R, Sijm A, van Teeffelen H, van Es R, Vos H, Timmers H
J Biol Chem
. 2016 Oct;
291(46):24121-24132.
PMID: 27703004
Gene-specific transcription factors (GSTFs) control gene transcription by DNA binding and specific protein complex recruitment, which regulates promoter accessibility for transcription initiation by RNA polymerase II. Mutations in the GSTFs...
10.
Koster M, Snel B, Timmers H
Cell
. 2015 May;
161(4):724-36.
PMID: 25957681
Histone proteins compact and stabilize the genomes of Eukarya and Archaea. By forming nucleosome(-like) structures they restrict access of DNA-binding transcription regulators to cis-regulatory DNA elements. Dynamic competition between histones...