Jesper Q Svejstrup
Overview
Explore the profile of Jesper Q Svejstrup including associated specialties, affiliations and a list of published articles.
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Articles
107
Citations
4388
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Recent Articles
1.
van den Heuvel D, Rodriguez-Martinez M, van der Meer P, Nieto Moreno N, Park J, Kim H, et al.
Cell
. 2024 Nov;
187(25):7107-7125.e25.
PMID: 39547229
Transcription-coupled DNA repair (TCR) removes bulky DNA lesions impeding RNA polymerase II (RNAPII) transcription. Recent studies have outlined the stepwise assembly of TCR factors CSB, CSA, UVSSA, and transcription factor...
2.
Blears D, Lou J, Fong N, Mitter R, Sheridan R, He D, et al.
Mol Cell
. 2024 Nov;
84(24):4790-4807.e11.
PMID: 39504960
The biological purpose of Integrator and RNA polymerase II (RNAPII) promoter-proximal pausing remains uncertain. Here, we show that loss of INTS6 in human cells results in increased interaction of RNAPII...
3.
Han Z, Svejstrup J
STAR Protoc
. 2024 Oct;
5(4):103369.
PMID: 39392748
We present a protocol for the in vitro detection of spontaneous termination of yeast RNA polymerase II (RNAPII) transcription using bead-immobilized elongation complexes (ECs). We describe the steps for EC...
4.
Fabian Z, Kakulidis E, Hendriks I, Kuhbacher U, Larsen N, Oliva-Santiago M, et al.
Nat Commun
. 2024 Aug;
15(1):6641.
PMID: 39103378
DNA-protein crosslinks (DPCs) are toxic lesions that inhibit DNA related processes. Post-translational modifications (PTMs), including SUMOylation and ubiquitylation, play a central role in DPC resolution, but whether other PTMs are...
5.
Lopez Martinez D, Svejstrup J
J Mol Biol
. 2024 Aug;
437(1):168735.
PMID: 39098594
RNA polymerase II (RNAPII) is responsible for the synthesis of a diverse set of RNA molecules, including protein-coding messenger RNAs (mRNAs) and many short non-coding RNAs (ncRNAs). For this purpose,...
6.
van den Heuvel D, Rodriguez-Martinez M, van der Meer P, Nieto Moreno N, Park J, Kim H, et al.
bioRxiv
. 2024 Aug;
PMID: 39091731
Transcription-coupled DNA repair (TCR) removes bulky DNA lesions impeding RNA polymerase II (RNAPII) transcription. Recent studies have outlined the stepwise assembly of TCR factors CSB, CSA, UVSSA, and TFIIH around...
7.
Lafuente-Barquero J, Svejstrup J, Luna R, Aguilera A
Mol Genet Genomics
. 2024 May;
299(1):59.
PMID: 38796829
RECQL5 is a member of the conserved RecQ family of DNA helicases involved in the maintenance of genome stability that is specifically found in higher eukaryotes and associates with the...
8.
Han Z, Moore G, Mitter R, Lopez Martinez D, Wan L, Dirac Svejstrup A, et al.
Mol Cell
. 2023 Sep;
83(18):3253-3267.e7.
PMID: 37683646
RNA polymerase II (RNAPII) transcription involves initiation from a promoter, transcriptional elongation through the gene, and termination in the terminator region. In bacteria, terminators often contain specific DNA elements provoking...
9.
Nieto Moreno N, Olthof A, Svejstrup J
Annu Rev Biochem
. 2023 Apr;
92:81-113.
PMID: 37040775
Ultraviolet (UV) irradiation and other genotoxic stresses induce bulky DNA lesions, which threaten genome stability and cell viability. Cells have evolved two main repair pathways to remove such lesions: global...
10.
Gregersen L, Mitter R, Svejstrup J
Cell Rep Methods
. 2023 Jan;
2(12):100368.
PMID: 36590686
Transcription of protein-coding genes is regulated by dynamic association of co-factors with RNA polymerase II (RNAPII). The function of these factors and their relationship with RNAPII is often poorly understood....