G H Hockerman
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Explore the profile of G H Hockerman including associated specialties, affiliations and a list of published articles.
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11
Citations
379
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Recent Articles
1.
Shabbir W, Beyl S, Timin E, Schellmann D, Erker T, Hohaus A, et al.
Br J Pharmacol
. 2010 Oct;
162(5):1074-82.
PMID: 20973779
Background And Purpose: Diltiazem inhibits Ca(V)1.2 channels and is widely used in clinical practice to treat cardiovascular diseases. Binding determinants for diltiazem are located on segments IIIS6, IVS6 and the...
2.
Hockerman G, Dilmac N, Scheuer T, Catterall W
Mol Pharmacol
. 2000 Nov;
58(6):1264-70.
PMID: 11093762
The benzothiazepine diltiazem blocks ionic current through L-type Ca(2+) channels, as do the dihydropyridines (DHPs) and phenylalkylamines (PAs), but it has unique properties that distinguish it from these other drug...
3.
Hockerman G, Peterson B, Sharp E, Tanada T, Scheuer T, Catterall W
Proc Natl Acad Sci U S A
. 1998 Feb;
94(26):14906-11.
PMID: 9405712
The activity of L-type Ca2+ channels is increased by dihydropyridine (DHP) agonists and inhibited by DHP antagonists, which are widely used in the therapy of cardiovascular disease. These drugs bind...
4.
Hockerman G, Johnson B, Abbott M, Scheuer T, Catterall W
J Biol Chem
. 1997 Jul;
272(30):18759-65.
PMID: 9228049
Recent studies of the phenylalkylamine binding site in the alpha1C subunit of L-type Ca2+ channels have revealed three amino acid residues in transmembrane segment IVS6 that are critical for high...
5.
Peterson B, Johnson B, Hockerman G, Acheson M, Scheuer T, Catterall W
J Biol Chem
. 1997 Jul;
272(30):18752-8.
PMID: 9228048
The dihydropyridine Ca2+ antagonist drugs used in the therapy of cardiovacular disorders inhibit L-type Ca2+ channels by binding to a single high affinity site. Photoaffinity labeling and analysis of mutant...
6.
Herlitze S, Hockerman G, Scheuer T, Catterall W
Proc Natl Acad Sci U S A
. 1997 Feb;
94(4):1512-6.
PMID: 9037084
Synaptic transmission is regulated by G protein-coupled receptors whose activation releases G protein betagamma subunits that modulate presynaptic Ca2+ channels. The sequence motif QXXER has been proposed to be involved...
7.
Johnson B, Brousal J, Peterson B, Gallombardo P, Hockerman G, Lai Y, et al.
J Neurosci
. 1997 Feb;
17(4):1243-55.
PMID: 9006969
Ca2+ influx through skeletal muscle Ca2+ channels and the force of contraction are increased in response to beta-adrenergic stimulation and high-frequency electrical stimulation. These effects are thought to be mediated...
8.
Hockerman G, Peterson B, Johnson B, Catterall W
Annu Rev Pharmacol Toxicol
. 1997 Jan;
37:361-96.
PMID: 9131258
The crucial role of L-type Ca2+ channels in the initiation of cardiac and smooth muscle contraction has made them major therapeutic targets for the treatment of cardiovascular disease. L-type channels...
9.
Johnson B, Hockerman G, Scheuer T, Catterall W
Mol Pharmacol
. 1996 Nov;
50(5):1388-400.
PMID: 8913371
The phenylalkylamines (-)-D888, verapamil, and D600, cause voltage- and use-dependent block of L-type Ca2+ channels and differ from each other only in the number of methoxy groups on each of...
10.
Hockerman G, Girvin M, Malbon C, Ruoho A
Mol Pharmacol
. 1996 Jun;
49(6):1021-32.
PMID: 8649340
The interactions between beta-adrenergic receptor (beta AR) antagonists and the beta(2)AR were studied with the use of photoaffinity labels. A proteolytic map of the receptor was made and confirmed through...