C C Malbon
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Explore the profile of C C Malbon including associated specialties, affiliations and a list of published articles.
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168
Citations
2438
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Recent Articles
1.
Wang H, Malbon C
Acta Physiol (Oxf)
. 2011 May;
204(1):65-73.
PMID: 21535414
The phosphoprotein scaffold Dishevelled is an essential component of both Wnt signalling and of the signalsome that constitutes the supermolecular 'punctae' of assembled proteins often observed in fluorescence microscopy. The...
2.
Port J, Malbon C
Trends Cardiovasc Med
. 2011 Jan;
3(3):85-92.
PMID: 21244945
The heart is a point of convergence for many transmembrane signal transduction pathways and, as such, exemplifies the complexities of sorting out their interactions. In the heart and cardiovascular system,...
3.
Malbon C, Tao J, Shumay E, Wang H
Biochem Soc Trans
. 2004 Oct;
32(Pt 5):861-4.
PMID: 15494034
AKAPs (A-kinase anchoring proteins) are members of a diverse family of scaffold proteins that minimally possess a characteristic binding domain for the RI/RII regulatory subunit of protein kinase A and...
4.
Wang H, Lee Y, Malbon C
Biochem Soc Trans
. 2004 Oct;
32(Pt 5):792-6.
PMID: 15494017
Wnt signalling in development operates via members of the Frizzleds, G-protein-coupled receptors that bind specific Wnt ligands and mediate signalling via distinct pathways. The Wnt/Ca(2+)/cGMP pathway mediated by Frizzled-2 was...
5.
Wang H, Malbon C
Cell Mol Life Sci
. 2004 Jan;
61(1):69-75.
PMID: 14704854
Wnt proteins signal via cell surface receptors termed Frizzleds. Frizzleds display many properties characteristic of members of the superfamily of G-protein-coupled receptors, including heptihelical hydropathy plots; an exofacial N-terminal region...
6.
Doronin S, Shumay E, Wang H, Malbon C
Biochem Biophys Res Commun
. 2001 Oct;
288(1):151-5.
PMID: 11594766
Lithium is a monovalent cation used therapeutically to treat a range of affective disorders (1), although the cellular mechanisms of lithium regulation that might contribute to its therapeutic effects at...
7.
Malbon C, Wang H, Moon R
Biochem Biophys Res Commun
. 2001 Sep;
287(3):589-93.
PMID: 11563835
Wnts are secreted ligands with diverse roles in animal development. Wnts bind to cell surface membrane proteins termed Frizzleds. Molecular cloning of members of the Frizzled family revealed hydropathy plots...
8.
Tao J, Malbon C, Wang H
J Biol Chem
. 2001 Aug;
276(43):39705-12.
PMID: 11500506
Suppression of the expression of the heterotrimeric G-protein Galpha(i2) in vivo has been shown to provoke insulin resistance, whereas enhanced insulin signaling is observed when Galpha(i2) is overexpressed in vivo....
9.
Song X, Zheng X, Malbon C, Wang H
J Biol Chem
. 2001 Jul;
276(37):34651-8.
PMID: 11457861
Heterotrimeric G-proteins, including Galpha(i2), have been implicated in modulating glucose disposal and insulin signaling. This cross-talk between G-protein-coupled and tyrosine kinase-coupled signaling pathways is a focal point for the study...
10.
Tao J, Malbon C, Wang H
J Biol Chem
. 2001 Jun;
276(31):29520-5.
PMID: 11395511
Protein-tyrosine phosphatase (PTP) 1B has been implicated in negative regulation of insulin action, although little is known of the ability of insulin to regulate PTP1B itself. The ability of insulin...