G Aaron Hobbs
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Explore the profile of G Aaron Hobbs including associated specialties, affiliations and a list of published articles.
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29
Citations
2667
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Recent Articles
1.
Robinson R, Reyes L, Christopher B, Duncan R, Burge R, Siegel J, et al.
Antibodies (Basel)
. 2024 Dec;
13(4).
PMID: 39727484
Background/objectives: Anterior Gradient-2 (AGR2/PDIA17) is a member of the protein disulfide isomerase (PDI) family of oxidoreductases. AGR2 is up-regulated in several solid tumors, including pancreatic ductal adenocarcinoma (PDAC). Given the...
2.
Bian Z, Benjamin M, Bialousow L, Tian Y, Hobbs G, Karan D, et al.
Heliyon
. 2024 Jul;
10(12):e33204.
PMID: 39022099
Sine oculis homeoprotein 1 (SIX1), a prominent representative of the homeodomain transcription factors within the SIX family, has attracted significant interest owing to its role in tumorigenesis, cancer progression, and...
3.
Ferretti G, Quaas C, Bertolini I, Zuccotti A, Saatci O, Kashatus J, et al.
Cell Death Differ
. 2024 May;
31(7):881-896.
PMID: 38802657
Pancreatic ductal adenocarcinoma (PDAC), the most prevalent type of pancreatic cancer, is one of the deadliest forms of cancer with limited therapy options. Overexpression of the heat shock protein 70...
4.
Schaefer A, Hodge R, Zhang H, Hobbs G, Dilly J, Huynh M, et al.
Sci Signal
. 2023 Dec;
16(816):eadg5289.
PMID: 38113333
Cancer-associated mutations in the guanosine triphosphatase (GTPase) RHOA are found at different locations from the mutational hotspots in the structurally and biochemically related RAS. Tyr-to-Cys (Y42C) and Leu-to-Val (L57V) substitutions...
5.
Huynh M, Hobbs G, Schaefer A, Pierobon M, Carey L, Diehl J, et al.
Sci Signal
. 2022 Aug;
15(746):eabn2694.
PMID: 35944066
Missense mutations at the three hotspots in the guanosine triphosphatase (GTPase) RAS-Gly, Gly, and Gln (commonly known as G12, G13, and Q61, respectively)-occur differentially among the three RAS isoforms. Q61...
6.
Lefler J, MarElia-Bennett C, Thies K, Hildreth 3rd B, Sharma S, Pitarresi J, et al.
Life Sci Alliance
. 2022 Jul;
5(11).
PMID: 35803738
Pancreatic ductal adenocarcinoma (PDAC) is associated with an incredibly dense stroma, which contributes to its recalcitrance to therapy. Cancer-associated fibroblasts (CAFs) are one of the most abundant cell types within...
7.
Huynh M, Parsonage D, Forshaw T, Chirasani V, Hobbs G, Wu H, et al.
J Biol Chem
. 2022 Jun;
298(8):102186.
PMID: 35753348
The recent development of mutant-selective inhibitors for the oncogenic KRAS allele has generated considerable excitement. These inhibitors covalently engage the mutant C12 thiol located within the phosphoryl binding loop of...
8.
Hobbs G, Der C
Subcell Biochem
. 2022 Apr;
98:205-221.
PMID: 35378710
Macropinocytosis is a critical route of nutrient acquisition in pancreatic cancer cells. Constitutive macropinocytosis is promoted by mutant KRAS, which activates the PI3Kα lipid kinase and RAC1, to drive membrane...
9.
Javaid S, Schaefer A, Goodwin C, Nguyen V, Massey F, Pierobon M, et al.
Mol Cancer Ther
. 2022 Mar;
21(5):762-774.
PMID: 35247914
Human papilloma virus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is a common cancer worldwide with an unmet need for more effective, less toxic treatments. Currently, both the disease...
10.
Khan I, Koide A, Zuberi M, Ketavarapu G, Denbaum E, Teng K, et al.
Cell Rep
. 2022 Feb;
38(6):110322.
PMID: 35139380
RAS guanosine triphosphatases (GTPases) are mutated in nearly 20% of human tumors, making them an attractive therapeutic target. Following our discovery that nucleotide-free RAS (apo RAS) regulates cell signaling, we...