G Aaron Hobbs
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Explore the profile of G Aaron Hobbs including associated specialties, affiliations and a list of published articles.
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29
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2667
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Recent Articles
11.
Burge R, Hobbs G
Adv Cancer Res
. 2022 Feb;
153:29-61.
PMID: 35101234
The RAS family of small GTPases are among the most frequently mutated oncogenes in human cancer. Approximately 20% of cancers harbor a RAS mutation, and >150 different missense mutations have...
12.
Waters A, Khatib T, Papke B, Goodwin C, Hobbs G, Diehl J, et al.
Cell Rep
. 2021 Jun;
35(13):109291.
PMID: 34192548
To identify therapeutic targets for KRAS mutant pancreatic cancer, we conduct a druggable genome small interfering RNA (siRNA) screen and determine that suppression of BCAR1 sensitizes pancreatic cancer cells to...
13.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
14.
Escobar-Hoyos L, Penson A, Kannan R, Cho H, Pan C, Singh R, et al.
Cancer Cell
. 2020 Jun;
38(2):198-211.e8.
PMID: 32559497
Pancreatic ductal adenocarcinoma (PDAC) is driven by co-existing mutations in KRAS and TP53. However, how these mutations collaborate to promote this cancer is unknown. Here, we uncover sequence-specific changes in...
15.
Bryant K, Stalnecker C, Zeitouni D, Klomp J, Peng S, Tikunov A, et al.
Nat Med
. 2020 Jun;
26(6):982.
PMID: 32483362
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
16.
Hobbs G, Der C
Trends Biochem Sci
. 2020 May;
45(6):459-461.
PMID: 32413322
The RAS oncoprotein drives elevated macropinocytosis, a metabolic process essential for cancer growth. A recent study by Ramirez et al. elucidated a mechanism whereby RAS controls V-ATPase association with the...
17.
Hobbs G, Baker N, Miermont A, Thurman R, Pierobon M, Tran T, et al.
Cancer Discov
. 2019 Oct;
10(1):104-123.
PMID: 31649109
Allele-specific signaling by different KRAS alleles remains poorly understood. The mutation displays uneven prevalence among cancers that harbor the highest occurrence of mutations: It is rare (∼1%) in lung and...
18.
Hobbs G, Der C
Cancer Discov
. 2019 Jun;
9(6):696-698.
PMID: 31160330
In this issue of , Poulin and colleagues apply structural, biochemical, and biological profiling of two mutants of KRAS, one found most frequently in all cancers (G12D) and one found...
19.
Bryant K, Stalnecker C, Zeitouni D, Klomp J, Peng S, Tikunov A, et al.
Nat Med
. 2019 Mar;
25(4):628-640.
PMID: 30833752
Pancreatic ductal adenocarcinoma (PDAC) is characterized by KRAS- and autophagy-dependent tumorigenic growth, but the role of KRAS in supporting autophagy has not been established. We show that, to our surprise,...
20.
Waters A, Ozkan-Dagliyan I, Vaseva A, Fer N, Strathern L, Hobbs G, et al.
Sci Signal
. 2017 Sep;
10(498).
PMID: 28951536
There is intense interest in developing therapeutic strategies for RAS proteins, the most frequently mutated oncoprotein family in cancer. Development of effective anti-RAS therapies will be aided by the greater...