Frederick C Streich Jr
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Explore the profile of Frederick C Streich Jr including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
328
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0
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Recent Articles
1.
Jackson J, Frederick C Streich Jr , Pal A, Coricor G, Boston C, Brueckner C, et al.
Sci Signal
. 2024 Jul;
17(844):eadn6052.
PMID: 38980922
Inhibitors of the transforming growth factor-β (TGF-β) pathway are potentially promising antifibrotic therapies, but nonselective simultaneous inhibition of all three TGF-β homologs has safety liabilities. TGF-β1 is noncovalently bound to...
2.
Martin C, Datta A, Littlefield C, Kalra A, Chapron C, Wawersik S, et al.
Sci Transl Med
. 2020 Mar;
12(536).
PMID: 32213632
Despite breakthroughs achieved with cancer checkpoint blockade therapy (CBT), many patients do not respond to anti-programmed cell death-1 (PD-1) due to primary or acquired resistance. Human tumor profiling and preclinical...
3.
Dagbay K, Treece E, Frederick C Streich Jr , Jackson J, Faucette R, Nikiforov A, et al.
J Biol Chem
. 2020 Feb;
295(16):5404-5418.
PMID: 32075906
Myostatin (or growth/differentiation factor 8 (GDF8)) is a member of the transforming growth factor β superfamily of growth factors and negatively regulates skeletal muscle growth. Its dysregulation is implicated in...
4.
Frederick C Streich Jr , Lima C
Methods Mol Biol
. 2018 Sep;
1844:169-196.
PMID: 30242710
Most cellular functions rely on pathways that catalyze posttranslational modification of cellular proteins by ubiquitin (Ub) and ubiquitin-like (Ubl) proteins. Like other posttranslational modifications that require distinct writers, readers, and...
5.
Frederick C Streich Jr , Lima C
Nature
. 2016 Aug;
536(7616):304-8.
PMID: 27509863
Post-translational protein modification by ubiquitin (Ub) and ubiquitin-like (Ubl) proteins such as small ubiquitin-like modifier (SUMO) regulates processes including protein homeostasis, the DNA damage response, and the cell cycle. Proliferating...
6.
Edwards D, Frederick C Streich Jr , Ronchi V, Todaro D, Haas A
J Biol Chem
. 2014 Oct;
289(49):34114-28.
PMID: 25342744
The human pathogen Shigella flexneri subverts host function and defenses by deploying a cohort of effector proteins via a type III secretion system. The IpaH family of 10 such effectors...
7.
Frederick C Streich Jr , Lima C
Annu Rev Biophys
. 2014 Apr;
43:357-79.
PMID: 24773014
Attachment of ubiquitin (Ub) and ubiquitin-like proteins (Ubls) to cellular proteins regulates numerous cellular processes including transcription, the cell cycle, stress responses, DNA repair, apoptosis, immune responses, and autophagy, to...
8.
Frederick C Streich Jr , Ronchi V, Connick J, Haas A
J Biol Chem
. 2013 Feb;
288(12):8209-8221.
PMID: 23408431
Ligation of polyubiquitin chains to proteins is a fundamental post-translational modification, often resulting in targeted degradation of conjugated proteins. Attachment of polyubiquitin chains requires the activities of an E1 activating...
9.
Frederick C Streich Jr , Haas A
Subcell Biochem
. 2011 Jan;
54:1-16.
PMID: 21222269
Attachment of ubiquitin and ubiquitin-like proteins to cellular targets represents a fundamental regulatory strategy within eukaryotes and exhibits remarkably pleiotropic effects on cell function. These posttranslational modifications share a common...