Christopher D Lima
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Explore the profile of Christopher D Lima including associated specialties, affiliations and a list of published articles.
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118
Citations
6409
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Recent Articles
1.
Baytshtok V, DiMattia M, Lima C
bioRxiv
. 2025 Jan;
PMID: 39763778
The human nucleoporin RanBP2/Nup358 interacts with SUMO1-modified RanGAP1 and the SUMO E2 Ubc9 at the nuclear pore complex (NPC) to promote export and disassembly of exportin Crm1/Ran(GTP)/cargo complexes. In mitosis,...
2.
Kochanczyk T, Fishman M, Lima C
Chembiochem
. 2024 Sep;
26(1):e202400659.
PMID: 39313481
Conjugation of ubiquitin (Ub) and structurally related ubiquitin-like proteins (Ubls), essential for many cellular processes, employs multi-step reactions orchestrated by specific E1, E2 and E3 enzymes. The E1 enzyme activates...
3.
Kochanczyk T, Hann Z, Lux M, Delos Reyes A, Ji C, Tan D, et al.
Nature
. 2024 Aug;
633(8028):216-223.
PMID: 39143218
Transthiolation (also known as transthioesterification) reactions are used in the biosynthesis of acetyl coenzyme A, fatty acids and polyketides, and for post-translational modification by ubiquitin (Ub) and ubiquitin-like (Ubl) proteins....
4.
Delos Reyes A, Lux M, Hann Z, Ji C, Kochanczyk T, DiBello M, et al.
Org Lett
. 2024 May;
26(22):4594-4599.
PMID: 38781175
Ubiquitin (Ub) regulates a wide array of cellular processes through post-translational modification of protein substrates. Ub is conjugated at its C-terminus to target proteins via an enzymatic cascade in which...
5.
Lee H, Lemmon A, Lima C
Proc Natl Acad Sci U S A
. 2022 Dec;
120(1):e2213703120.
PMID: 36574706
The Ufd1/Npl4/Cdc48 complex is a universal protein segregase that plays key roles in eukaryotic cellular processes. Its functions orchestrating the clearance or removal of polyubiquitylated targets are established; however, prior...
6.
Puno M, Lima C
Methods Enzymol
. 2022 Aug;
673:453-473.
PMID: 35965016
The nuclear RNA exosome collaborates with the MTR4 helicase and RNA adaptor complexes to process, surveil, and degrade RNA. Here we outline methods to characterize RNA translocation and strand displacement...
7.
Puno M, Lima C
Cell
. 2022 Jun;
185(12):2132-2147.e26.
PMID: 35688134
RNA quality control relies on co-factors and adaptors to identify and prepare substrates for degradation by ribonucleases such as the 3' to 5' ribonucleolytic RNA exosome. Here, we determined cryogenic...
8.
Saito Y, Hawley B, Puno M, Sarathy S, Lima C, Jaffrey S, et al.
Genes Dev
. 2022 Jan;
36(3-4):180-194.
PMID: 35058317
Mechanisms regulating meiotic progression in mammals are poorly understood. The -methyladenosine (mA) reader and 3' → 5' RNA helicase YTHDC2 switches cells from mitotic to meiotic gene expression programs and...
9.
Cappadocia L, Kochanczyk T, Lima C
EMBO J
. 2021 Sep;
40(22):e103787.
PMID: 34585421
Repair of DNA double-stranded breaks by homologous recombination (HR) is dependent on DNA end resection and on post-translational modification of repair factors. In budding yeast, single-stranded DNA is coated by...
10.
Das M, Zattas D, Zinder J, Wasmuth E, Henri J, Lima C
Proc Natl Acad Sci U S A
. 2021 Mar;
118(14).
PMID: 33782132
Quality control requires discrimination between functional and aberrant species to selectively target aberrant substrates for destruction. Nuclear RNA quality control in includes the TRAMP complex that marks RNA for decay...