Frederic Lopez
Overview
Explore the profile of Frederic Lopez including associated specialties, affiliations and a list of published articles.
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Articles
45
Citations
1333
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Recent Articles
1.
Lumeau A, Bery N, Frances A, Gayral M, Labrousse G, Ribeyre C, et al.
Cancer Res
. 2024 Jan;
84(7):1013-1028.
PMID: 38294491
Significance: Cytidine deaminase reduces replication stress and regulates DNA replication to confer resistance to DNA-damaging drugs in pancreatic cancer, unveiling a molecular vulnerability that could enhance treatment response.
2.
Pont F, Cerapio J, Gravelle P, Ligat L, Valle C, Sarot E, et al.
BMC Bioinformatics
. 2023 Jan;
24(1):30.
PMID: 36707753
Background: The development of single-cell technologies yields large datasets of information as diverse and multimodal as transcriptomes, immunophenotypes, and spatial position from tissue sections in the so-called 'spatial transcriptomics'. Currently...
3.
Rouanet M, Hanoun N, Lulka H, Ferreira C, Garcin P, Sramek M, et al.
Mol Ther
. 2022 Jan;
30(4):1553-1563.
PMID: 35038581
Toll-like receptors (TLRs) are key players in the innate immune system. Recent studies have suggested that they may affect the growth of pancreatic cancer, a disease with no cure. Among...
4.
Domagala M, Ysebaert L, Ligat L, Lopez F, Fournie J, Laurent C, et al.
Cancers (Basel)
. 2022 Jan;
14(1).
PMID: 35008174
Tumor-associated macrophages (TAMs) in chronic lymphocytic leukemia (CLL) are also called nurse-like cells (NLC), and confer survival signals through the release of soluble factors and cellular contacts. While in most...
5.
Cerapio J, Perrier M, Balanca C, Gravelle P, Pont F, Devaud C, et al.
Oncoimmunology
. 2021 Nov;
10(1):1939518.
PMID: 34721945
γδ T lymphocytes diverge from conventional T CD8 lymphocytes for ontogeny, homing, and antigen specificity, but whether their differentiation in tumors also deviates was unknown. Using innovative analyses of our...
6.
Laplagne C, Ligat L, Foote J, Lopez F, Fournie J, Laurent C, et al.
Cell Mol Immunol
. 2021 Jun;
18(8):1861-1870.
PMID: 34183807
The high cytotoxic activity of Vγ9Vδ2 T lymphocytes against tumor cells makes them useful candidates in anticancer therapies. However, the molecular mechanism of their activation by phosphoantigens (PAgs) is not...
7.
Morigny P, Houssier M, Mairal A, Ghilain C, Mouisel E, Benhamed F, et al.
Nat Metab
. 2020 Jul;
1(1):133-146.
PMID: 32694809
Impaired adipose tissue insulin signalling is a critical feature of insulin resistance. Here we identify a pathway linking the lipolytic enzyme hormone-sensitive lipase (HSL) to insulin action via the glucose-responsive...
8.
Alard A, Marboeuf C, Fabre B, Jean C, Martineau Y, Lopez F, et al.
Front Genet
. 2019 Apr;
10:254.
PMID: 30984242
The 4G family of eukaryotic mRNA translation initiation factors is composed of three members (eIF4GI, eIF4GII, and DAP5). Their specific roles in translation initiation are under intense investigations, but how...
9.
Perchey R, Tonini L, Tosolini M, Fournie J, Lopez F, Besson A, et al.
Sci Rep
. 2019 Mar;
9(1):4181.
PMID: 30862887
Discovery of protein modification sites relies on protein digestion by proteases and mass spectrometry (MS) identification of the modified peptides. Depending on proteases used and target protein sequence, this method...
10.
Hedir S, De Giorgi M, Fogha J, De Pascale M, Weiswald L, Brotin E, et al.
Eur J Med Chem
. 2018 Oct;
159:357-380.
PMID: 30308410
Protein-protein interactions are attractive targets because they control numerous cellular processes. In oncology, apoptosis regulating Bcl-2 family proteins are of particular interest. Apoptotic cell death is controlled via PPIs between...