Cytidine Deaminase Resolves Replicative Stress and Protects Pancreatic Cancer from DNA-Targeting Drugs

Overview

Journal Cancer Res

Specialty Oncology

Date 2024 Jan 31

PMID 38294491

Authors

Audrey Lumeau

Nicolas Bery

Audrey Frances

Marion Gayral

Guillaume Labrousse

Cyril Ribeyre

Charlene Lopez

Adele Nevot

Abdessamad El Kaoutari

Naima Hanoun

Emeline Sarot

Marion Perrier

Frederic Pont

Juan-Pablo Cerapio

Jean-Jacques Fournie

Frederic Lopez

Miguel Madrid-Mencia

Vera Pancaldi

Marie-Jeanne Pillaire

Valerie Bergoglio

Jerome Torrisani

Nelson Dusetti

Jean-Sebastien Hoffmann

Louis Buscail

Malik Lutzmann

Pierre Cordelier

Affiliations

Soon will be listed here.

Abstract

Significance: Cytidine deaminase reduces replication stress and regulates DNA replication to confer resistance to DNA-damaging drugs in pancreatic cancer, unveiling a molecular vulnerability that could enhance treatment response.

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