Florian Markowetz
Overview
Explore the profile of Florian Markowetz including associated specialties, affiliations and a list of published articles.
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Articles
97
Citations
8267
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Recent Articles
1.
Morrill Gavarro L, Couturier D, Markowetz F
BMC Bioinformatics
. 2025 Feb;
26(1):59.
PMID: 39966709
Background: Mutational processes of diverse origin leave their imprints in the genome during tumour evolution. These imprints are called mutational signatures and they have been characterised for point mutations, structural...
2.
Whitmarsh T, Cope W, Carmona-Bozo J, Manavaki R, Sammut S, Woitek R, et al.
Breast Cancer Res
. 2025 Feb;
27(1):17.
PMID: 39905431
Background: Tumour vascular density assessed from CD-31 immunohistochemistry (IHC) images has previously been shown to have prognostic value in breast cancer. Current methods to measure vascular density, however, are time-consuming,...
3.
Baykal P, Labaj P, Markowetz F, Schriml L, Stekhoven D, Mangul S, et al.
Genome Biol
. 2024 Aug;
25(1):213.
PMID: 39123217
In biomedical research, validating a scientific discovery hinges on the reproducibility of its experimental results. However, in genomics, the definition and implementation of reproducibility remain imprecise. We argue that genomic...
4.
Stella de Biase M, Massip F, Wei T, Giorgi F, Stark R, Stone A, et al.
Genome Med
. 2024 Apr;
16(1):54.
PMID: 38589970
Background: Lung cancer is the leading cause of cancer-related death in the world. In contrast to many other cancers, a direct connection to modifiable lifestyle risk in the form of...
5.
Zhao W, Rose S, Blake R, Godicelj A, Cullen A, Stenning J, et al.
J Mol Endocrinol
. 2024 Apr;
73(1).
PMID: 38564418
The estrogen receptor-α (ER) drives 75% of breast cancers. On activation, the ER recruits and assembles a 1-2 MDa transcriptionally active complex. These complexes can modulate tumour growth, and understanding...
6.
Schneider M, Cullen A, Pangonyte J, Skelton J, Major H, Van Oudenhove E, et al.
Genome Biol
. 2024 Mar;
25(1):62.
PMID: 38438920
Cancer cells often exhibit DNA copy number aberrations and can vary widely in their ploidy. Correct estimation of the ploidy of single-cell genomes is paramount for downstream analysis. Based only...
7.
All models are wrong and yours are useless: making clinical prediction models impactful for patients
Markowetz F
NPJ Precis Oncol
. 2024 Feb;
8(1):54.
PMID: 38418530
No abstract available.
8.
Crispin-Ortuzar M, Woitek R, Reinius M, Moore E, Beer L, Bura V, et al.
Nat Commun
. 2023 Oct;
14(1):6756.
PMID: 37875466
High grade serous ovarian carcinoma (HGSOC) is a highly heterogeneous disease that typically presents at an advanced, metastatic state. The multi-scale complexity of HGSOC is a major obstacle to predicting...
9.
Smith P, Bradley T, Morrill Gavarro L, Goranova T, Ennis D, Mirza H, et al.
Nat Commun
. 2023 Sep;
14(1):5992.
PMID: 37752102
No abstract available.
10.
Berman A, Orchard W, Gehrung M, Markowetz F
PLoS One
. 2023 Aug;
18(8):e0289499.
PMID: 37549131
The inspection of stained tissue slides by pathologists is essential for the early detection, diagnosis and monitoring of disease. Recently, deep learning methods for the analysis of whole-slide images (WSIs)...