Andrew N Holding
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Explore the profile of Andrew N Holding including associated specialties, affiliations and a list of published articles.
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21
Citations
355
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Recent Articles
1.
Malcolm J, Bridge K, Holding A, Brackenbury W
BMC Genomics
. 2025 Jan;
26(1):59.
PMID: 39838295
Hypoxia is common in breast tumours and is linked to therapy resistance and advanced disease. To understand hypoxia-driven breast cancer progression, RT-qPCR is a widely used technique to quantify transcriptional...
2.
Beck D, Cao H, Tian F, Huang Y, Jiang M, Zhao H, et al.
Nat Commun
. 2024 Nov;
15(1):9697.
PMID: 39516193
The epigenetic landscape plays a critical role in cancer progression, yet its therapeutic potential remains underexplored. Glucocorticoids are essential components of treatments for lymphoid cancers, but resistance, driven in part...
3.
Capatina A, Malcolm J, Stenning J, Moore R, Bridge K, Brackenbury W, et al.
Front Cell Dev Biol
. 2024 Sep;
12:1421629.
PMID: 39282472
The events that control breast cancer progression and metastasis are complex and intertwined. Hypoxia plays a key role both in oncogenic transformation and in fueling the metastatic potential of breast...
4.
Leslie T, Tripp A, James A, Fraser S, Nelson M, Sajjaboontawee N, et al.
Oncogene
. 2024 Jul;
43(34):2578-2594.
PMID: 39048659
Solid tumours have abnormally high intracellular [Na]. The activity of various Na channels may underlie this Na accumulation. Voltage-gated Na channels (VGSCs) have been shown to be functionally active in...
5.
Zhao W, Rose S, Blake R, Godicelj A, Cullen A, Stenning J, et al.
J Mol Endocrinol
. 2024 Apr;
73(1).
PMID: 38564418
The estrogen receptor-α (ER) drives 75% of breast cancers. On activation, the ER recruits and assembles a 1-2 MDa transcriptionally active complex. These complexes can modulate tumour growth, and understanding...
6.
Holding A, McIntyre K, Lynch P
FEBS J
. 2022 Nov;
290(8):2022-2028.
PMID: 36447362
Metrics play a vital part in the valuation and funding of research for scientists worldwide. We review the challenges that metrics pose in providing a fair and equitable system for...
7.
Adam R, van Neerven S, Pleguezuelos-Manzano C, Simmini S, Leveille N, de Groot N, et al.
Cancer Cell Int
. 2020 Dec;
20(1):578.
PMID: 33292279
Background: Cancer results from the accumulation of mutations leading to the acquisition of cancer promoting characteristics such as increased proliferation and resistance to cell death. In colorectal cancer, an early...
8.
Mercatelli D, Holding A, Giorgi F
Brief Bioinform
. 2020 Oct;
22(2):690-700.
PMID: 33057582
The current outbreak of COVID-19 has generated an unprecedented scientific response worldwide, with the generation of vast amounts of publicly available epidemiological, biological and clinical data. Bioinformatics scientists have quickly...
9.
Holding A, Cook H, Markowetz F
Biochim Biophys Acta Gene Regul Mech
. 2019 Nov;
1863(6):194441.
PMID: 31756390
Recent advances in single-cell RNA-sequencing (scRNA-seq) in combination with CRISPR/Cas9 technologies have enabled the development of methods for large-scale perturbation studies with transcriptional readouts. These methods are highly scalable and...
10.
Holding A
FEBS J
. 2019 Jun;
286(20):3975-3979.
PMID: 31250544
The pressures of a scientific career can end up incentivising an all-or-nothing approach to cross the finish line first. While competition can be healthy and drives innovation, the current system...