Felix J Hartmann
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Explore the profile of Felix J Hartmann including associated specialties, affiliations and a list of published articles.
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30
Citations
2523
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Recent Articles
1.
Greenwald N, Nederlof I, Sowers C, Ding D, Park S, Kong A, et al.
bioRxiv
. 2025 Feb;
PMID: 39975273
Immune checkpoint inhibition (ICI) has fundamentally changed cancer treatment. However, only a minority of patients with metastatic triple negative breast cancer (TNBC) benefit from ICI, and the determinants of response...
2.
Cosgrove J, Marcais A, Hartmann F, Bergthaler A, Zanoni I, Corrado M, et al.
Nat Metab
. 2024 Apr;
6(5):779-782.
PMID: 38605184
No abstract available.
3.
Adamik J, Munson P, Maurer D, Hartmann F, Bendall S, Arguello R, et al.
Nat Commun
. 2023 Nov;
14(1):7211.
PMID: 37938561
Efficacy of cancer vaccines remains low and mechanistic understanding of antigen presenting cell function in cancer may improve vaccine design and outcomes. Here, we analyze the transcriptomic and immune-metabolic profiles...
4.
Mrdjen D, Amouzgar M, Cannon B, Liu C, Spence A, McCaffrey E, et al.
Res Sq
. 2023 Jul;
PMID: 37398389
Microglia are implicated in aging, neurodegeneration, and Alzheimer's disease (AD). Traditional, low-plex, imaging methods fall short of capturing cellular states and interactions in the human brain. We utilized Multiplexed Ion...
5.
Robinson M, Glass D, Duran V, Agudelo Rojas O, Sanz A, Consuegra M, et al.
Sci Adv
. 2023 Mar;
9(12):eade7702.
PMID: 36961888
Approximately 5 million dengue virus-infected patients progress to a potentially life-threatening severe dengue (SD) infection annually. To identify the immune features and temporal dynamics underlying SD progression, we performed deep...
6.
Munson P, Adamik J, Hartmann F, Favaro P, Ho D, Bendall S, et al.
Cancer Res
. 2023 Feb;
83(9):1543-1557.
PMID: 36847613
Significance: α-Fetoprotein (AFP) is a secreted tumor protein and biomarker with impact on immunity. Fatty acid-bound AFP promotes immune suppression by skewing human dendritic cell metabolism toward glycolysis and reduced...
7.
Adamik J, Munson P, Hartmann F, Combes A, Pierre P, Krummel M, et al.
Nat Commun
. 2022 Sep;
13(1):5184.
PMID: 36056019
Cellular metabolism underpins immune cell functionality, yet our understanding of metabolic influences in human dendritic cell biology and their ability to orchestrate immune responses is poorly developed. Here, we map...
8.
Amouzgar M, Glass D, Baskar R, Averbukh I, Kimmey S, Tsai A, et al.
Patterns (N Y)
. 2022 Aug;
3(8):100536.
PMID: 36033591
Single-cell technologies generate large, high-dimensional datasets encompassing a diversity of omics. Dimensionality reduction captures the structure and heterogeneity of the original dataset, creating low-dimensional visualizations that contribute to the human...
9.
Ackerman S, Pearson C, Gregorio J, Gonzalez J, Kenkel J, Hartmann F, et al.
Nat Cancer
. 2022 Feb;
2(1):18-33.
PMID: 35121890
Innate pattern recognition receptor agonists, including Toll-like receptors (TLRs), alter the tumor microenvironment and prime adaptive antitumor immunity. However, TLR agonists present toxicities associated with widespread immune activation after systemic...
10.
Geeraerts X, Fernandez-Garcia J, Hartmann F, de Goede K, Martens L, Elkrim Y, et al.
Cell Rep
. 2021 Dec;
37(13):110171.
PMID: 34965415
Macrophages are often prominently present in the tumor microenvironment, where distinct macrophage populations can differentially affect tumor progression. Although metabolism influences macrophage function, studies on the metabolic characteristics of ex ...