Lukas M Weber
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Explore the profile of Lukas M Weber including associated specialties, affiliations and a list of published articles.
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25
Citations
1993
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Recent Articles
1.
Tippani M, Divecha H, Catallini 2nd J, Kwon S, Weber L, Spangler A, et al.
Biol Imaging
. 2024 Mar;
3:e23.
PMID: 38510173
Spatially resolved transcriptomics (SRT) is a growing field that links gene expression to anatomical context. SRT approaches that use next-generation sequencing (NGS) combine RNA sequencing with histological or fluorescent imaging...
2.
Weber L, Divecha H, Tran M, Kwon S, Spangler A, Montgomery K, et al.
Elife
. 2024 Jan;
12.
PMID: 38266073
Norepinephrine (NE) neurons in the locus coeruleus (LC) make long-range projections throughout the central nervous system, playing critical roles in arousal and mood, as well as various components of cognition...
3.
Hippen A, Omran D, Weber L, Jung E, Drapkin R, Doherty J, et al.
Genome Biol
. 2023 Oct;
24(1):239.
PMID: 37864274
Background: Single-cell gene expression profiling provides unique opportunities to understand tumor heterogeneity and the tumor microenvironment. Because of cost and feasibility, profiling bulk tumors remains the primary population-scale analytical strategy....
4.
Weber L, Saha A, Datta A, Hansen K, Hicks S
Nat Commun
. 2023 Jul;
14(1):4059.
PMID: 37429865
Feature selection to identify spatially variable genes or other biologically informative genes is a key step during analyses of spatially-resolved transcriptomics data. Here, we propose nnSVG, a scalable approach to...
5.
Krieg C, Weber L, Fosso B, Marzano M, Hardiman G, Olcina M, et al.
J Immunother Cancer
. 2022 Sep;
10(9).
PMID: 36137652
Background And Aims: The role of inflammatory immune responses in colorectal cancer (CRC) development and response to therapy is a matter of intense debate. While inflammation is a known driver...
6.
Petrillo M, Fabbri M, Kagkli D, Querci M, Van den Eede G, Alm E, et al.
F1000Res
. 2022 Jul;
10:80.
PMID: 35847383
Next Generation Sequencing technologies significantly impact the field of Antimicrobial Resistance (AMR) detection and monitoring, with immediate uses in diagnosis and risk assessment. For this application and in general, considerable...
7.
Pardo B, Spangler A, Weber L, Page S, Hicks S, Jaffe A, et al.
BMC Genomics
. 2022 Jun;
23(1):434.
PMID: 35689177
Background: Spatially-resolved transcriptomics has now enabled the quantification of high-throughput and transcriptome-wide gene expression in intact tissue while also retaining the spatial coordinates. Incorporating the precise spatial mapping of gene...
8.
Righelli D, Weber L, Crowell H, Pardo B, Collado-Torres L, Ghazanfar S, et al.
Bioinformatics
. 2022 Apr;
38(11):3128-3131.
PMID: 35482478
Summary: SpatialExperiment is a new data infrastructure for storing and accessing spatially-resolved transcriptomics data, implemented within the R/Bioconductor framework, which provides advantages of modularity, interoperability, standardized operations and comprehensive documentation....
9.
Weber L, Hippen A, Hickey P, Berrett K, Gertz J, Doherty J, et al.
Gigascience
. 2021 Sep;
10(9).
PMID: 34553212
Background: Pooling cells from multiple biological samples prior to library preparation within the same single-cell RNA sequencing experiment provides several advantages, including lower library preparation costs and reduced unwanted technological...
10.
Liechti T, Weber L, Ashhurst T, Stanley N, Prlic M, Van Gassen S, et al.
Nat Immunol
. 2021 Sep;
22(10):1190-1197.
PMID: 34489590
No abstract available.