Felix Gunawan
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Explore the profile of Felix Gunawan including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
243
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Recent Articles
1.
Albu M, Affolter E, Gentile A, Xu Y, Kikhi K, Howard S, et al.
Nat Commun
. 2024 Sep;
15(1):8159.
PMID: 39289341
Tissues undergo distinct morphogenetic processes to achieve similarly shaped structures. In the heart, cardiomyocytes in both the ventricle and atrium build internal structures for efficient contraction. Ventricular wall formation (trabeculation)...
2.
Bornhorst D, Hejjaji A, Steuter L, Woodhead N, Maier P, Gentile A, et al.
Nat Commun
. 2024 Aug;
15(1):7589.
PMID: 39217144
The contribution of endocardial cells (EdCs) to the hematopoietic lineages has been strongly debated. Here, we provide evidence that in zebrafish, the endocardium gives rise to and maintains a stable...
3.
Gentile A, Albu M, Xu Y, Mortazavi N, Ribeiro da Silva A, Stainier D, et al.
Development
. 2024 Jul;
151(13).
PMID: 38984541
The cardiac extracellular matrix (cECM) is fundamental for organ morphogenesis and maturation, during which time it undergoes remodeling, yet little is known about whether mechanical forces generated by the heartbeat...
4.
Ribeiro da Silva A, Gunawan F, Boezio G, Faure E, Theron A, Avierinos J, et al.
Sci Adv
. 2024 May;
10(20):eadl0633.
PMID: 38748804
Biomechanical forces, and their molecular transducers, including key mechanosensitive transcription factor genes, such as , are required for cardiac valve morphogenesis. However, mutants fail to completely recapitulate the valveless phenotype...
5.
Boezio G, Zhao S, Gollin J, Priya R, Mansingh S, Guenther S, et al.
Dis Model Mech
. 2022 Sep;
16(5).
PMID: 36172839
The epicardium, the outermost layer of the heart, is an important regulator of cardiac regeneration. However, a detailed understanding of the crosstalk between the epicardium and myocardium during development requires...
6.
Gentile A, Bensimon-Brito A, Priya R, Maischein H, Piesker J, Guenther S, et al.
Elife
. 2021 Jun;
10.
PMID: 34152269
The transcription factor Snai1, a well-known regulator of epithelial-to-mesenchymal transition, has been implicated in early cardiac morphogenesis as well as in cardiac valve formation. However, a role for Snai1 in...
7.
Gunawan F, Priya R, Stainier D
Curr Opin Cell Biol
. 2021 Jun;
73:26-34.
PMID: 34147705
The transformation of the heart from a simple tube to a complex organ requires the orchestration of several morphogenetic processes. Two structures critical for cardiac function, the cardiac valves and...
8.
Gunawan F, Gentile A, Gauvrit S, Stainier D, Bensimon-Brito A
Circ Res
. 2020 Feb;
126(8):968-984.
PMID: 32070236
Rationale: The transcription factor NFATC1 (nuclear factor of activated T-cell 1) has been implicated in cardiac valve formation in humans and mice, but we know little about the underlying mechanisms....
9.
Fukuda R, Gunawan F, Ramadass R, Beisaw A, Konzer A, Mullapudi S, et al.
Dev Cell
. 2019 Sep;
51(1):62-77.e5.
PMID: 31495694
Mechanical forces regulate cell behavior and tissue morphogenesis. During cardiac development, mechanical stimuli from the heartbeat are required for cardiomyocyte maturation, but the underlying molecular mechanisms remain unclear. Here, we...
10.
Gunawan F, Gentile A, Fukuda R, Tsedeke A, Jimenez-Amilburu V, Ramadass R, et al.
J Cell Biol
. 2019 Jan;
218(3):1039-1054.
PMID: 30635353
Elucidating the morphogenetic events that shape vertebrate heart valves, complex structures that prevent retrograde blood flow, is critical to understanding valvular development and aberrations. Here, we used the zebrafish atrioventricular...