Didier Y R Stainier
Overview
Explore the profile of Didier Y R Stainier including associated specialties, affiliations and a list of published articles.
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Articles
271
Citations
18304
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Recent Articles
1.
Gupta S, Bajwa G, El-Sammak H, Mattonet K, Gunther S, Looso M, et al.
Dev Biol
. 2025 Feb;
521:153-162.
PMID: 39983908
Myocardial infarction occurs when the coronary supply of oxygen and nutrients to part of the heart is interrupted. In contrast to adult mammals, adult zebrafish have a remarkable ability to...
2.
Falcucci L, Dooley C, Adamoski D, Juan T, Martinez J, Georgieva A, et al.
Nature
. 2025 Feb;
639(8054):493-502.
PMID: 39939773
Duchenne muscular dystrophy (DMD) is a muscle-degenerating disease caused by mutations in the DMD gene, which encodes the dystrophin protein. Utrophin (UTRN), the genetic and functional paralogue of DMD, is...
3.
Juan T, Molina T, Xie L, Papadopoulou S, Cardoso B, Jha S, et al.
PLoS Genet
. 2025 Feb;
21(2):e1011594.
PMID: 39919116
Precise regulation of gene expression is essential to understand a wide range of biological processes. Control over gene expression can be achieved using site-directed recombinases and endonucleases whose efficiency is...
4.
Leerberg D, Avillion G, Priya R, Stainier D, Yelon D
bioRxiv
. 2025 Jan;
PMID: 39829878
Cardiac chambers emerge from a heart tube that balloons and bends to create expanded ventricular and atrial structures, each containing a convex outer curvature (OC) and a recessed inner curvature...
5.
Juvik B, Falcucci L, Lundegaard P, Stainier D
Trends Genet
. 2025 Jan;
41(3):187-193.
PMID: 39788833
The onset and progression of dominant diseases are thought to result from haploinsufficiency or dominant negative effects. Here, we propose transcriptional adaptation (TA), a newly identified response to mRNA decay,...
6.
Xu Y, Gehlot R, Capon S, Albu M, Gretz J, Bloomekatz J, et al.
Nat Cardiovasc Res
. 2024 Dec;
3(12):1531-1548.
PMID: 39658721
The basic helix-loop-helix transcription factor HAND2 has multiple roles during vertebrate organogenesis, including cardiogenesis. However, much remains to be uncovered about its mechanism of action. Here, we show the generation...
7.
Wang Z, Mehra A, Wang Q, Gupta S, Ribeiro da Silva A, Juan T, et al.
Development
. 2024 Nov;
151(23).
PMID: 39612288
VEGFA administration has been explored as a pro-angiogenic therapy for cardiovascular diseases including heart failure for several years, but with little success. Here, we investigate a different approach to augment...
8.
Schmitner N, Thumer S, Regele D, Mayer E, Bergerweiss I, Helker C, et al.
Commun Biol
. 2024 Nov;
7(1):1557.
PMID: 39580550
Glucokinase (GCK) is an essential enzyme for blood glucose homeostasis. Because of its importance in glucose metabolism, GCK is considered an attractive target for the development of antidiabetic drugs. However,...
9.
Prieto-Garcia C, Matkovic V, Mosler T, Li C, Liang J, Oo J, et al.
Science
. 2024 Nov;
386(6723):768-776.
PMID: 39541449
RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanisms and cellular responses remain...
10.
Liu Z, Lu C, Ma L, Li C, Luo H, Liu Y, et al.
Adv Sci (Weinh)
. 2024 Oct;
11(44):e2308622.
PMID: 39360593
Abnormalities of tracheal smooth muscle (SM) formation are associated with several clinical disorders including tracheal stenosis and tracheomalacia. However, the cellular and molecular mechanisms underlying tracheal SM formation remain poorly...