Fabien Alpy
Overview
Explore the profile of Fabien Alpy including associated specialties, affiliations and a list of published articles.
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Articles
43
Citations
1133
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Recent Articles
1.
Eichler J, Huver S, Knorr C, Wendling C, Kobayashi T, Tomasetto C, et al.
Methods Mol Biol
. 2024 Dec;
2888:101-118.
PMID: 39699727
Cholesterol is a key component of biological membranes and, like many cellular lipids, is unevenly distributed among organelles. Disruptions in cholesterol trafficking are associated with various pathologies, including lysosomal lipid...
2.
Mishra S, Manohar V, Chandel S, Manoj T, Bhattacharya S, Hegde N, et al.
Life Sci Alliance
. 2024 Mar;
7(6).
PMID: 38499328
Lipid transfer proteins mediate the transfer of lipids between organelle membranes, and the loss of function of these proteins has been linked to neurodegeneration. However, the mechanism by which loss...
3.
Moliere S, Lodi M, Leblanc S, Gressel A, Mathelin C, Alpy F, et al.
BMC Cancer
. 2024 Mar;
24(1):295.
PMID: 38438841
Background: Early hormone-positive breast cancers typically have favorable outcomes, yet long-term surveillance is crucial due to the risk of late recurrences. While many studies associate MMP-11 expression with poor prognosis...
4.
Moliere S, Martinet A, Jaulin A, Lodi M, Chamaraux-Tran T, Alpy F, et al.
J Mammary Gland Biol Neoplasia
. 2024 Jan;
29(1):2.
PMID: 38289494
In preclinical studies, accurate monitoring of tumor dynamics is crucial for understanding cancer biology and evaluating therapeutic interventions. Traditional methods like caliper measurements and bioluminescence imaging (BLI) have limitations, prompting...
5.
Lodi M, Voilquin L, Alpy F, Moliere S, Reix N, Mathelin C, et al.
Cancers (Basel)
. 2023 Jan;
15(2).
PMID: 36672312
Methods: We conducted a retrospective study between 2007 and 2020 on 112 patients with non-metastatic HER2-positive breast cancer treated by NST and then by surgery. We developed an immunohistochemistry assay...
6.
Lemesle M, Geoffroy M, Alpy F, Tomasetto C, Kuntz S, Grillier-Vuissoz I
Cancers (Basel)
. 2022 Oct;
14(20).
PMID: 36291810
Triple-negative breast cancer (TNBC) is an aggressive subtype that constitutes 15-20% of breast cancer cases worldwide. Current therapies often evolve into chemoresistance and lead to treatment failure. About 77% of...
7.
Zouiouich M, Di Mattia T, Martinet A, Eichler J, Wendling C, Tomishige N, et al.
J Cell Biol
. 2022 Apr;
221(6).
PMID: 35389430
Membrane contact sites between organelles are organized by protein bridges. Among the components of these contacts, the VAP family comprises ER-anchored proteins, such as MOSPD2, that function as major ER-organelle...
8.
Milanini J, Magdeleine M, Fuggetta N, Ikhlef S, Brau F, Abelanet S, et al.
J Biol Chem
. 2022 Mar;
298(5):101780.
PMID: 35231443
Membrane contact sites are specialized areas where the membranes of two distinct organelles are physically connected and allow for the exchange of molecules and for signaling processes. Understanding the mechanisms...
9.
Awan S, Lambert M, Imtiaz A, Alpy F, Tomasetto C, Oulad-Abdelghani M, et al.
Circ Res
. 2021 Dec;
130(2):184-199.
PMID: 34886684
Background: Impairment of cellular cholesterol trafficking is at the heart of atherosclerotic lesions formation. This involves egress of cholesterol from the lysosomes and 2 lysosomal proteins, the NPC1 (Niemann-Pick C1)...
10.
Di Mattia T, Martinet A, Ikhlef S, McEwen A, Nomine Y, Wendling C, et al.
EMBO J
. 2020 Oct;
39(23):e104369.
PMID: 33124732
Organelles are physically connected in membrane contact sites. The endoplasmic reticulum possesses three major receptors, VAP-A, VAP-B, and MOSPD2, which interact with proteins at the surface of other organelles to...