Lea P Wilhelm
Overview
Explore the profile of Lea P Wilhelm including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
273
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Recent Articles
1.
Wilhelm L, Ganley I
EMBO J
. 2023 Jun;
42(13):e114542.
PMID: 37272260
How mitophagy is turned on to remove damaged or excess mitochondria from cells has been well-studied, but less is known about how the pathway is turned off to avoid "over-eating"...
2.
PINK1-Dependent Mitophagy Inhibits Elevated Ubiquitin Phosphorylation Caused by Mitochondrial Damage
Lambourne O, Bell S, Wilhelm L, Yarbrough E, Holly G, Russell O, et al.
J Med Chem
. 2023 May;
66(11):7645-7656.
PMID: 37248632
Ubiquitin phosphorylation by the mitochondrial protein kinase PTEN-induced kinase 1 (PINK1), upon mitochondrial depolarization, is an important intermediate step in the recycling of damaged mitochondria via mitophagy. As mutations in...
3.
Wilhelm L, Ganley I
Autophagy
. 2022 Dec;
19(7):2162-2163.
PMID: 36572844
Mitochondria, often called "the powerhouse" of the cell due to their role as the main energy supplier, regulate numerous complex processes including intracellular calcium homeostasis, reactive oxygen species (ROS) production,...
4.
Wilhelm L, Zapata-Munoz J, Villarejo-Zori B, Pellegrin S, Martins Freire C, Toye A, et al.
EMBO J
. 2022 Oct;
41(24):e111115.
PMID: 36215693
Mitochondria and peroxisomes are closely related metabolic organelles, both in terms of origin and in terms of function. Mitochondria and peroxisomes can also be turned over by autophagy, in processes...
5.
Wilhelm L, Voilquin L, Kobayashi T, Tomasetto C, Alpy F
Methods Mol Biol
. 2019 Feb;
1949:137-152.
PMID: 30790254
Cholesterol, a major component of biological membranes, is rapidly trafficked and unevenly distributed between organelles. Anomalies of intracellular cholesterol distribution are the hallmark of a number of lysosomal lipid storage...
6.
Di Mattia T, Wilhelm L, Ikhlef S, Wendling C, Spehner D, Nomine Y, et al.
EMBO Rep
. 2018 Jun;
19(7).
PMID: 29858488
Membrane contact sites are cellular structures that mediate interorganelle exchange and communication. The two major tether proteins of the endoplasmic reticulum (ER), VAP-A and VAP-B, interact with proteins from other...
7.
Wilhelm L, Wendling C, Vedie B, Kobayashi T, Chenard M, Tomasetto C, et al.
EMBO J
. 2017 Apr;
36(10):1412-1433.
PMID: 28377464
StAR-related lipid transfer domain-3 (STARD3) is a sterol-binding protein that creates endoplasmic reticulum (ER)-endosome contact sites. How this protein, at the crossroad between sterol uptake and synthesis pathways, impacts the...
8.
Wilhelm L, Tomasetto C, Alpy F
Biochem Soc Trans
. 2016 Apr;
44(2):493-8.
PMID: 27068960
Membrane contact sites (MCSs) are subcellular regions where the membranes of distinct organelles come into close apposition. These specialized areas of the cell, which are involved in inter-organelle metabolite exchange,...
9.
Rousseau A, Wilhelm L, Tomasetto C, Alpy F
Tissue Barriers
. 2015 Jan;
2(4):e975597.
PMID: 25610759
Tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4), a protein localized in TJs in normal epithelial cells, is frequently overexpressed in carcinomas. We recently found that TRAF4 impedes TJ formation/stability...