Ester M Hammond
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Explore the profile of Ester M Hammond including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Leszczynska K, Dzwigonska M, Estephan H, Moehlenbrink J, Bowler E, Giaccia A, et al.
Mol Oncol
. 2023 Apr;
17(7):1173-1191.
PMID: 37013907
Local hypoxia occurs in most solid tumors and is associated with aggressive disease and therapy resistance. Widespread changes in gene expression play a critical role in the biological response to...
12.
Rodriguez-Berriguete G, Ranzani M, Prevo R, Puliyadi R, Machado N, Bolland H, et al.
Clin Cancer Res
. 2023 Jan;
29(8):1631-1642.
PMID: 36689546
Purpose: DNA polymerase theta (Polθ, encoded by the POLQ gene) is a DNA repair enzyme critical for microhomology mediated end joining (MMEJ). Polθ has limited expression in normal tissues but...
13.
Wallabregue A, Bolland H, Faulkner S, Hammond E, Conway S
J Am Chem Soc
. 2023 Jan;
145(4):2572-2583.
PMID: 36656915
Hypoxia (low oxygen levels) occurs in a range of biological contexts, including plants, bacterial biofilms, and solid tumors; it elicits responses from these biological systems that impact their survival. For...
14.
Worth K, Papandreou I, Hammond E
Br J Cancer
. 2022 Nov;
128(3):407-412.
PMID: 36344595
Pivotal research led by Louis Harold Gray in the 1950s suggested that oxygen plays a vital role during radiotherapy. By proving that tumours have large necrotic cores due to hypoxia...
15.
Koyasu S, Horita S, Saito K, Kobayashi M, Ishikita H, Chow C, et al.
EMBO Rep
. 2022 Nov;
24(1):e54042.
PMID: 36341521
Aberrant activation of the hypoxia-inducible transcription factor HIF-1 and dysfunction of the tumor suppressor p53 have been reported to induce malignant phenotypes and therapy resistance of cancers. However, their mechanistic...
16.
Sekirnik A, Reynolds J, See L, Bluck J, Scorah A, Tallant C, et al.
ACS Chem Biol
. 2022 Sep;
17(10):2753-2768.
PMID: 36098557
TRIM33 is a member of the tripartite motif (TRIM) family of proteins, some of which possess E3 ligase activity and are involved in the ubiquitin-dependent degradation of proteins. Four of...
17.
Bolland H, Hammond E, Sedgwick A
Chem Commun (Camb)
. 2022 Sep;
58(76):10699-10702.
PMID: 36069107
Aryl boronate fluorescent probes allow the non-invasive study of dynamic cellular processes involving the reactive species, hydrogen peroxide (HO) and peroxynitrite (ONOO). However, the ability of these probes to differentiate...
18.
Celora G, Bader S, Hammond E, Maini P, Pitt-Francis J, Byrne H
J Theor Biol
. 2022 Mar;
545:111104.
PMID: 35337794
New experimental data have shown how the periodic exposure of cells to low oxygen levels (i.e., cyclic hypoxia) impacts their progress through the cell-cycle. Cyclic hypoxia has been detected in...
19.
Higgins G, Hammond E
Br J Cancer
. 2022 Feb;
126(7):971-972.
PMID: 35197582
The link between hypoxic conditions and radiation sensitivity is well-established, however the dynamic nature of hypoxia is often overlooked. The contribution of acute/transient hypoxia versus chronic conditions to radiosensitivity has...
20.
Suwa T, Kobayashi M, Shirai Y, Nam J, Tabuchi Y, Takeda N, et al.
JCI Insight
. 2021 Nov;
6(21).
PMID: 34747365
Hypoxia is associated with tumor radioresistance; therefore, a predictive marker for tumor hypoxia and a rational target to overcome it have been sought to realize personalized radiotherapy. Here, we show...