Ester M Hammond
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Explore the profile of Ester M Hammond including associated specialties, affiliations and a list of published articles.
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Recent Articles
21.
Troelsen K, Calder E, Skwarska A, Sneddon D, Hammond E, Conway S
ChemMedChem
. 2021 Jul;
16(24):3691-3700.
PMID: 34259396
We report the synthesis and biological evaluation of a light-activated (caged) prodrug of the KDAC inhibitor panobinostat (Zap-Pano). We demonstrate that addition of the 4,5-dimethoxy-2-nitrobenzyl group to the hydroxamic acid...
22.
Brand M, Clayton J, Moroglu M, Schiedel M, Picaud S, Bluck J, et al.
J Med Chem
. 2021 Jul;
64(14):10102-10123.
PMID: 34255515
CREBBP (CBP/KAT3A) and its paralogue EP300 (KAT3B) are lysine acetyltransferases (KATs) that are essential for human development. They each comprise 10 domains through which they interact with >400 proteins, making...
23.
Bader S, Ma T, Simpson C, Liang J, Maezono S, Olcina M, et al.
Nucleic Acids Res
. 2021 Jul;
49(13):7492-7506.
PMID: 34197599
Tumor heterogeneity includes variable and fluctuating oxygen concentrations, which result in the accumulation of hypoxic regions in most solid tumors. Tumor hypoxia leads to increased therapy resistance and has been...
24.
Ramachandran S, Ma T, Griffin J, Ng N, Foskolou I, Hwang M, et al.
Nat Commun
. 2021 Jun;
12(1):3686.
PMID: 34140498
Tumour hypoxia is associated with poor patient prognosis and therapy resistance. A unique transcriptional response is initiated by hypoxia which includes the rapid activation of numerous transcription factors in a...
25.
Bolland H, Ma T, Ramlee S, Ramadan K, Hammond E
Biochem Soc Trans
. 2021 May;
49(3):1251-1263.
PMID: 34003246
Hypoxia is a feature of most solid tumours and predicts for poor prognosis. In radiobiological hypoxia (<0.1% O2) cells become up to three times more resistant to radiation. The biological...
26.
Skwarska A, Calder E, Sneddon D, Bolland H, Odyniec M, Mistry I, et al.
Cell Chem Biol
. 2021 Apr;
28(9):1258-1270.e13.
PMID: 33910023
Tumor hypoxia is associated with therapy resistance and poor patient prognosis. Hypoxia-activated prodrugs, designed to selectively target hypoxic cells while sparing normal tissue, represent a promising treatment strategy. We report...
27.
Marti J, Garcia-Diaz A, Delgado-Bellido D, OValle F, Gonzalez-Flores A, Carlevaris O, et al.
Redox Biol
. 2021 Feb;
41:101885.
PMID: 33581682
Background: The adaptation to hypoxia is mainly controlled by the HIF transcription factors. Increased expression/activity of HIF-1α correlates with poor prognosis in cancer patients. PARP-1 inhibitors are used in the...
28.
Wing P, Liu P, Harris J, Magri A, Michler T, Zhuang X, et al.
J Hepatol
. 2021 Jan;
75(1):64-73.
PMID: 33516779
Background & Aims: Hypoxia inducible factors (HIFs) are a hallmark of inflammation and are key regulators of hepatic immunity and metabolism, yet their role in HBV replication is poorly defined....
29.
Bader S, Dewhirst M, Hammond E
Cancers (Basel)
. 2020 Dec;
13(1).
PMID: 33374581
Regions of hypoxia occur in most if not all solid cancers. Although the presence of tumor hypoxia is a common occurrence, the levels of hypoxia and proportion of the tumor...
30.
Bowler E, Skwarska A, Wilson J, Ramachandran S, Bolland H, Easton A, et al.
iScience
. 2020 Nov;
23(11):101668.
PMID: 33134898
Inhibition of the ATR kinase has emerged as a therapeutically attractive means to target cancer since the development of potent inhibitors, which are now in clinical testing. We investigated a...