Eric W J Gates
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Explore the profile of Eric W J Gates including associated specialties, affiliations and a list of published articles.
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9
Citations
36
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Recent Articles
1.
Ancona P, Trentini A, Terrazzan A, Grassilli S, Navals P, Gates E, et al.
J Mol Biol
. 2024 Apr;
436(10):168569.
PMID: 38604527
Transglutaminase 2 (TG2) performs many functions both under physiological and pathological conditions. In cancer, its expression is associated with aggressiveness, propensity to epithelial-mesenchymal transition, and metastasis. Since TG2 performs key...
2.
Gates E, Prince-Hallee A, Heidari Y, Sedighi A, Keillor J
Biochemistry
. 2023 Oct;
62(21):3085-3095.
PMID: 37856791
Transglutaminases (TGases) are a family of calcium-dependent enzymes primarily known for their ability to cross-link proteins. Transglutaminase 2 (TG2) is one isozyme in this family whose role is multifaceted. TG2...
3.
Gates E, Calvert N, Cundy N, Brugnoli F, Navals P, Kirby A, et al.
Int J Mol Sci
. 2023 Aug;
24(16).
PMID: 37628729
Transglutaminase 2 (TG2) is a multifunctional enzyme primarily responsible for crosslinking proteins. Ubiquitously expressed in humans, TG2 can act either as a transamidase by crosslinking two substrates through formation of...
4.
Cundy N, Arciszewski J, Gates E, Acton S, Passley K, Awoonor-Williams E, et al.
RSC Med Chem
. 2023 Feb;
14(2):378-385.
PMID: 36846375
Transglutaminase 2 (TG2), also referred to as tissue transglutaminase, plays crucial roles in both protein crosslinking and cell signalling. It is capable of both catalysing transamidation and acting as a...
5.
Gates E, Mansour K, Samani S, Shad S, Kaartinen M, Keillor J
Molecules
. 2023 Feb;
28(4).
PMID: 36838622
Factor XIIIa (FXIIIa) is a transglutaminase of major therapeutic interest for the development of anticoagulants due to its essential role in the blood coagulation cascade. While numerous FXIIIa inhibitors have...
6.
Canella R, Brugnoli F, Gallo M, Keillor J, Terrazzan A, Ferrari E, et al.
Cancers (Basel)
. 2023 Jan;
15(1).
PMID: 36612174
Since the multifunctionality of transglutaminase 2 (TG2) includes extra- and intracellular functions, we investigated the effects of intracellular administration of TG2 inhibitors in three breast cancer cell lines, MDA-MB-231, MDA-MB-436...
7.
Rangaswamy A, Navals P, Gates E, Shad S, Watt S, Keillor J
RSC Med Chem
. 2022 Jun;
13(4):413-428.
PMID: 35647547
Tissue transglutaminase (TG2) is a multifunctional protein that plays biological roles based on its ability to catalyse protein cross-linking and to function as a non-canonical G-protein known as Ghα. The...
8.
McNeil N, Gates E, Firoozi N, Cundy N, Leccese J, Eisinga S, et al.
Eur J Med Chem
. 2022 Feb;
232:114172.
PMID: 35158154
Tissue transglutaminase (TG2) is a multifunctional protein that catalyses protein crosslinking in the extracellular matrix, and functions as an intracellular G-protein. While both activities have been associated with human diseases,...
9.
Rorke E, Adhikary G, Szmacinski H, Lakowicz J, Weber D, Godoy-Ruiz R, et al.
Mol Carcinog
. 2021 Oct;
61(1):19-32.
PMID: 34610184
Type 2 transglutaminase (TG2) functions as an important cancer cell survival protein in a range of cancers including epidermal squamous cell carcinoma. TG2 exists in open and closed conformations each...