Nicole M R McNeil
Overview
Explore the profile of Nicole M R McNeil including associated specialties, affiliations and a list of published articles.
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8
Citations
65
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Recent Articles
1.
Cundy N, Arciszewski J, Gates E, Acton S, Passley K, Awoonor-Williams E, et al.
RSC Med Chem
. 2023 Feb;
14(2):378-385.
PMID: 36846375
Transglutaminase 2 (TG2), also referred to as tissue transglutaminase, plays crucial roles in both protein crosslinking and cell signalling. It is capable of both catalysing transamidation and acting as a...
2.
McNeil N, Gates E, Firoozi N, Cundy N, Leccese J, Eisinga S, et al.
Eur J Med Chem
. 2022 Feb;
232:114172.
PMID: 35158154
Tissue transglutaminase (TG2) is a multifunctional protein that catalyses protein crosslinking in the extracellular matrix, and functions as an intracellular G-protein. While both activities have been associated with human diseases,...
3.
Akbar A, McNeil N, Albert M, Ta V, Adhikary G, Bourgeois K, et al.
J Med Chem
. 2017 Sep;
60(18):7910-7927.
PMID: 28858494
Human tissue transglutaminase (hTG2) is a multifunctional enzyme. It is primarily known for its calcium-dependent transamidation activity that leads to formation of an isopeptide bond between glutamine and lysine residues...
4.
McNeil N, Press D, Mayder D, Garnica P, Doyle L, Back T
J Org Chem
. 2016 Aug;
81(17):7884-97.
PMID: 27525346
Diaryl selenides containing o-hydroxymethylene substituents function as peroxide-destroying mimetics of the antioxidant selenoenzyme glutathione peroxidase (GPx), via oxidation to the corresponding spirodioxyselenuranes with hydrogen peroxide and subsequent reduction back to...
5.
McNeil N, McDonnell C, Hambrook M, Back T
Molecules
. 2015 Jun;
20(6):10748-62.
PMID: 26111166
Cyclic seleninate esters function as mimetics of the antioxidant selenoenzyme glutathione peroxidase. They catalyze the reduction of harmful peroxides with thiols, which are converted to disulfides in the process. The...
6.
Press D, McNeil N, Hambrook M, Back T
J Org Chem
. 2014 Sep;
79(19):9394-401.
PMID: 25198287
Cyclic seleninate esters function as mimetics of the antioxidant enzyme glutathione peroxidase and catalyze the reduction of hydrogen peroxide with a stoichiometric thiol. While a single electron-donating methoxy substituent para...
7.
McNeil N, Matz M, Back T
J Org Chem
. 2013 Sep;
78(20):10369-82.
PMID: 24032451
The oxidation of allyl selenide 12 with hydrogen peroxide produced the corresponding allyl selenurane 14, the cyclic seleninate ester 4, or the rearranged O-allyl seleninate ester 18, dependng on the...
8.
Press D, McNeil N, Rauk A, Back T
J Org Chem
. 2012 Sep;
77(20):9268-76.
PMID: 22974016
Spirodioxyselenurane 4a and several substituted analogs revealed unexpected (1)H NMR behavior. The diastereotopic methylene hydrogens of 4a appeared as an AB quartet at low temperature that coalesced to a singlet...