Pauline Navals
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Explore the profile of Pauline Navals including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
19
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Recent Articles
1.
Kang J, Jeon H, Lee J, Bae S, Park G, Min K, et al.
J Med Chem
. 2024 Oct;
67(21):19716-19735.
PMID: 39445793
Diabetic retinopathy is a disease that can cause vision loss leading to blindness in people with diabetes. Improved methods to treat and prevent vision loss in diabetic patients are in...
2.
Navals P, Rangaswamy A, Kasyanchyk P, Berezovski M, Keillor J
Biomolecules
. 2024 Apr;
14(4).
PMID: 38672511
TG2 is a unique member of the transglutaminase family as it undergoes a dramatic conformational change, allowing its mutually exclusive function as either a cross-linking enzyme or a G-protein. The...
3.
Ancona P, Trentini A, Terrazzan A, Grassilli S, Navals P, Gates E, et al.
J Mol Biol
. 2024 Apr;
436(10):168569.
PMID: 38604527
Transglutaminase 2 (TG2) performs many functions both under physiological and pathological conditions. In cancer, its expression is associated with aggressiveness, propensity to epithelial-mesenchymal transition, and metastasis. Since TG2 performs key...
4.
Gates E, Calvert N, Cundy N, Brugnoli F, Navals P, Kirby A, et al.
Int J Mol Sci
. 2023 Aug;
24(16).
PMID: 37628729
Transglutaminase 2 (TG2) is a multifunctional enzyme primarily responsible for crosslinking proteins. Ubiquitously expressed in humans, TG2 can act either as a transamidase by crosslinking two substrates through formation of...
5.
Navals P, Kwiatkowska A, Mekdad N, Couture F, Desjardins R, Day R, et al.
Mol Pharm
. 2023 Aug;
20(9):4559-4573.
PMID: 37555521
The enzyme PACE4 has been validated as a promising therapeutic target to expand the range of prostate cancer (PCa) treatments. In recent years, we have developed a potent peptidomimetic inhibitor,...
6.
Bonapace-Potvin M, Pepin M, Navals P, Medor M, Lorange E, Bensimon E
Aesthetic Plast Surg
. 2022 Nov;
47(4):1353-1361.
PMID: 36414725
Background: Facial gender-affirming surgery (FGAS) is described as a set of surgical procedures done to feminize the soft tissue and the facial skeleton, allowing for transfeminine individuals to be recognizable...
7.
Rangaswamy A, Navals P, Gates E, Shad S, Watt S, Keillor J
RSC Med Chem
. 2022 Jun;
13(4):413-428.
PMID: 35647547
Tissue transglutaminase (TG2) is a multifunctional protein that plays biological roles based on its ability to catalyse protein cross-linking and to function as a non-canonical G-protein known as Ghα. The...
8.
Lewandowska-Goch M, Kwiatkowska A, Lepek T, Ly K, Navals P, Gagnon H, et al.
ACS Med Chem Lett
. 2021 Mar;
12(3):365-372.
PMID: 33738063
Furin plays an important role in various pathological states, especially in bacterial and viral infections. A detailed understanding of the structural requirements for inhibitors targeting this enzyme is crucial to...
9.
Dianati V, Navals P, Couture F, Desjardins R, Dame A, Kwiatkowska A, et al.
J Med Chem
. 2018 Dec;
61(24):11250-11260.
PMID: 30501188
Paired basic amino acid cleaving enzyme 4 (PACE4), a serine endoprotease of the proprotein convertases family, has been recognized as a promising target for prostate cancer. We previously reported a...