Jeffrey W Keillor
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Explore the profile of Jeffrey W Keillor including associated specialties, affiliations and a list of published articles.
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102
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1087
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Recent Articles
1.
Abdallah D, Israelian J, Hasan L, Patel N, Keillor J, Wright T, et al.
Chem Commun (Camb)
. 2025 Mar;
PMID: 40063364
Targeted protein degradation (TPD) is revolutionizing drug discovery, but PROTAC synthesis remains challenging due to multi-step synthesis and slow linker installation SAr on 4-fluorothalidomide. Here, we optimize a microwave-assisted synthesis...
2.
Delgado T, Emerson J, Hong M, Keillor J, Johnson G
Biomolecules
. 2025 Jan;
14(12.
PMID: 39766301
Astrocytes play critical roles in supporting structural and metabolic homeostasis in the central nervous system (CNS). CNS injury leads to the development of a range of reactive phenotypes in astrocytes...
3.
Ryan B, Rangaswamy A, Shad S, Keillor J
Bioorg Med Chem Lett
. 2024 Dec;
119:130078.
PMID: 39708924
Tissue transglutaminase (TG2) is a multifunctional protein that can catalyze the cross-linking between proteins, and function as a G-protein. TG2's unregulated behaviour has been associated with fibrosis, celiac disease and...
4.
Mader L, Borean J, Keillor J
RSC Med Chem
. 2024 Nov;
PMID: 39526224
Irreversible targeted covalent inhibitors, in the past regarded as inappropriately reactive and toxic, have seen a recent resurgence in clinical interest. This paradigm shift is attributed to the exploitation of...
5.
Ly H, Almeneim H, Gill M, Keillor J, Beauchemin A
Org Lett
. 2024 Nov;
26(46):9885-9890.
PMID: 39508520
Despite major advances, intramolecular alkene hydroamination reactions often face limitations. Herein, a redox-enabled process featuring oxidation of an amine to a hydroxylamine, a concerted hydroamination step, followed by catalytic reduction...
6.
Kang J, Jeon H, Lee J, Bae S, Park G, Min K, et al.
J Med Chem
. 2024 Oct;
67(21):19716-19735.
PMID: 39445793
Diabetic retinopathy is a disease that can cause vision loss leading to blindness in people with diabetes. Improved methods to treat and prevent vision loss in diabetic patients are in...
7.
Hoffman E, Rangaswamy A, Cleveland M, Keillor J, Howe G
Angew Chem Int Ed Engl
. 2024 Oct;
64(2):e202414842.
PMID: 39441552
Plastics are ubiquitous in our ecosystems, and microplastic accumulation in the environment is an emerging global health concern. Since available recycling technologies are not economically competitive with primary plastic production,...
8.
Rangaswamy A, Roy F, Keillor J
Anal Biochem
. 2024 Jul;
693:115598.
PMID: 38964700
The widespread use of polyamides such as nylons has led to the accumulation of nylon waste, which is particularly resistant to decomposition due to the intrinsic stability of the amide...
9.
Mader L, Keillor J
ACS Med Chem Lett
. 2024 May;
15(5):731-738.
PMID: 38746886
Experiments comprising a "pre-incubation" phase, where enzyme is incubated with inhibitor prior to the addition of assay substrate, are commonly used to evaluate covalent inhibitors, often via discontinuous or "endpoint"...
10.
Navals P, Rangaswamy A, Kasyanchyk P, Berezovski M, Keillor J
Biomolecules
. 2024 Apr;
14(4).
PMID: 38672511
TG2 is a unique member of the transglutaminase family as it undergoes a dramatic conformational change, allowing its mutually exclusive function as either a cross-linking enzyme or a G-protein. The...