Eric V Shusta
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Explore the profile of Eric V Shusta including associated specialties, affiliations and a list of published articles.
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110
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4056
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Recent Articles
31.
Katt M, Shusta E
Curr Opin Chem Eng
. 2020 Sep;
30:42-52.
PMID: 32905326
Development of brain therapeutics is significantly hampered by the presence of the blood-brain barrier (BBB). Classical transwell models are able to recapitulate many important aspects of drug transport across the...
32.
Song H, Foreman K, Gastfriend B, Kuo J, Palecek S, Shusta E
Sci Rep
. 2020 Jul;
10(1):12358.
PMID: 32704093
The brain vasculature maintains brain homeostasis by tightly regulating ionic, molecular, and cellular transport between the blood and the brain parenchyma. These blood-brain barrier (BBB) properties are impediments to brain...
33.
Umlauf B, Shusta E
Methods Mol Biol
. 2020 Mar;
2133:221-233.
PMID: 32144670
Expressed protein ligation (EPL), using non-self-cleaving inteins, allows for the site-specific addition of customized chemical moieties to the termini of proteins. In this way, protein activity can be preserved while...
34.
Lajoie J, Cho Y, Frost D, Bremner S, Li L, Shusta E
Protein Eng Des Sel
. 2019 Nov;
32(5):219-230.
PMID: 31769480
Yeast display immunoprecipitation is a combinatorial library screening platform for the discovery and engineering of antibodies against membrane proteins using detergent-solubilized membrane fractions or cell lysates as antigen sources. Here,...
35.
Canfield S, Stebbins M, Faubion M, Gastfriend B, Palecek S, Shusta E
Fluids Barriers CNS
. 2019 Sep;
16(1):31.
PMID: 31506073
Following publication of the original article [1], the author has reported that in Figure 1 (b and c) the y-axis TEER (© x cm) should be replaced with TEER (Ω...
36.
Kim B, McDonagh M, Deng L, Gastfriend B, Schubert-Unkmeir A, Doran K, et al.
Fluids Barriers CNS
. 2019 Aug;
16(1):26.
PMID: 31434575
Bacterial meningitis is a serious life threatening infection of the CNS. To cause meningitis, blood-borne bacteria need to interact with and penetrate brain endothelial cells (BECs) that comprise the blood-brain...
37.
Canfield S, Stebbins M, Faubion M, Gastfriend B, Palecek S, Shusta E
Fluids Barriers CNS
. 2019 Aug;
16(1):25.
PMID: 31387594
Background: Brain microvascular endothelial cells (BMECs) astrocytes, neurons, and pericytes form the neurovascular unit (NVU). Interactions with NVU cells endow BMECs with extremely tight barriers via the expression of tight...
38.
Kim B, Shusta E, Doran K
Front Microbiol
. 2019 Jul;
10:1336.
PMID: 31263460
The central nervous system (CNS) barriers are highly specialized cellular barriers that promote brain homeostasis while restricting pathogen and toxin entry. The primary cellular constituent regulating pathogen entry in most...
39.
Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells as a Cellular Model to Study Infection
Martins Gomes S, Westermann A, Sauerwein T, Hertlein T, Forstner K, Ohlsen K, et al.
Front Microbiol
. 2019 Jun;
10:1181.
PMID: 31191497
Meningococcal meningitis is a severe central nervous system infection that occurs when () penetrates brain endothelial cells (BECs) of the meningeal blood-cerebrospinal fluid barrier. As a human-specific pathogen, models are...
40.
Bradley R, Shireman J, McFalls C, Choi J, Canfield S, Dong Y, et al.
Development
. 2019 Jun;
146(13).
PMID: 31189664
Astrocytes display diverse morphologies in different regions of the central nervous system. Whether astrocyte diversity is attributable to developmental processes and bears functional consequences, especially in humans, is unknown. RNA-seq...