Eric V Shusta
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Explore the profile of Eric V Shusta including associated specialties, affiliations and a list of published articles.
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110
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4056
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Recent Articles
21.
Nishihara H, Gastfriend B, Kasap P, Palecek S, Shusta E, Engelhardt B
STAR Protoc
. 2021 Jun;
2(2):100563.
PMID: 34151293
We describe the extended endothelial cell culture method (EECM) for the differentiation of human pluripotent stem cells (hPSCs) into brain microvascular endothelial cell (BMEC)-like cells. EECM-BMEC-like cells resemble primary human...
22.
Lee M, Stebbins M, Jiao H, Huang H, Leiferman E, Walczak B, et al.
Sci Adv
. 2021 Jun;
7(21).
PMID: 34138734
Generating phenotypic chondrocytes from pluripotent stem cells is of great interest in the field of cartilage regeneration. In this study, we differentiated human induced pluripotent stem cells into the mesodermal...
23.
Gastfriend B, Foreman K, Katt M, Palecek S, Shusta E
J Cereb Blood Flow Metab
. 2021 May;
41(11):3052-3068.
PMID: 34027687
Brain mural cells, including pericytes and vascular smooth muscle cells, are important for vascular development, blood-brain barrier function, and neurovascular coupling, but the molecular characteristics of human brain mural cells...
24.
Gastfriend B, Stebbins M, Du F, Shusta E, Palecek S
Curr Protoc
. 2021 Jan;
1(1):e21.
PMID: 33484491
Brain pericytes regulate diverse aspects of neurovascular development and function, including blood-brain barrier (BBB) induction and maintenance. Primary brain pericytes have been widely employed in coculture-based in vitro models of...
25.
Luo H, Shusta E
Pharmaceutics
. 2020 Nov;
12(11).
PMID: 33198244
The blood-brain barrier (BBB) is formed by brain microvascular endothelial cells that are sealed by tight junctions, making it a significant obstacle for most brain therapeutics. The poor BBB penetration...
26.
Nishihara H, Gastfriend B, Soldati S, Perriot S, Mathias A, Sano Y, et al.
FASEB J
. 2020 Oct;
34(12):16693-16715.
PMID: 33124083
Human induced pluripotent stem cell (hiPSC)-derived blood-brain barrier (BBB) models established to date lack expression of key adhesion molecules involved in immune cell migration across the BBB in vivo. Here,...
27.
Sun M, Chung H, Matsuk V, Fink D, Stebbins M, Palecek S, et al.
Front Cell Dev Biol
. 2020 Oct;
8:590539.
PMID: 33117819
Sonic hedgehog (Shh) pathway disruption causes craniofacial malformations including orofacial clefts (OFCs) of the lip and palate. In normal craniofacial morphogenesis, Shh signals to multipotent cranial neural crest cells (cNCCs)...
28.
Lippmann E, Azarin S, Palecek S, Shusta E
Fluids Barriers CNS
. 2020 Oct;
17(1):64.
PMID: 33076946
In 2012, we provided the first published evidence that human pluripotent stem cells could be differentiated to cells exhibiting markers and phenotypes characteristic of the blood-brain barrier (BBB). In the...
29.
Neuronal Activity Regulates Blood-Brain Barrier Efflux Transport through Endothelial Circadian Genes
Pulido R, Munji R, Chan T, Quirk C, Weiner G, Weger B, et al.
Neuron
. 2020 Sep;
108(5):937-952.e7.
PMID: 32979312
The blood vessels in the central nervous system (CNS) have a series of unique properties, termed the blood-brain barrier (BBB), which stringently regulate the entry of molecules into the brain,...
30.
Georgieva J, Goulatis L, Stutz C, Canfield S, Song H, Gastfriend B, et al.
FASEB J
. 2020 Sep;
34(9):12549-12564.
PMID: 32960493
Drug delivery across the blood-brain barrier (BBB) remains a significant obstacle for the development of neurological disease therapies. The low penetration of blood-borne therapeutics into the brain can oftentimes be...