Eric V Shusta
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Explore the profile of Eric V Shusta including associated specialties, affiliations and a list of published articles.
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110
Citations
4056
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Recent Articles
11.
Foreman K, Shusta E, Palecek S
Methods Mol Biol
. 2023 Jun;
2683:113-133.
PMID: 37300771
The blood-brain barrier (BBB) comprises brain microvascular endothelial cells (BMECs) that form a high-resistance cellular interface that separates the blood compartment from the brain parenchyma. An intact BBB is pivotal...
12.
Yan Q, Jacobson T, Ye Z, Cortes-Pena Y, Bhagwat S, Hubbard S, et al.
Metab Eng
. 2023 Jan;
76:18-28.
PMID: 36626963
Plants produce many high-value oleochemical molecules. While oil-crop agriculture is performed at industrial scales, suitable land is not available to meet global oleochemical demand. Worse, establishing new oil-crop farms often...
13.
Georgieva J, Katt M, Ye Z, Umlauf B, Wenthur C, Shusta E
Pharmaceutics
. 2022 Aug;
14(8).
PMID: 36015332
Central nervous system (CNS) exposure to blood-borne biotherapeutics is limited by the restrictive nature of the brain vasculature. In particular, tightly sealed endothelial cells of the blood-brain barrier (BBB) prevent...
14.
Umlauf B, Kuo J, Shusta E
Methods Mol Biol
. 2022 Apr;
2491:235-248.
PMID: 35482194
Extracellular matrix (ECM) is a rich mixture of proteins and glycans secreted by cells. This includes typical ECM structures such as collagen and heparin as well as glycosylated, secreted proteins...
15.
Lajoie J, Katt M, Waters E, Herrin B, Shusta E
Sci Rep
. 2022 Apr;
12(1):6044.
PMID: 35411012
The blood-brain barrier (BBB) represents a significant bottleneck for the delivery of therapeutics to the central nervous system. In recent years, the promise of coopting BBB receptor-mediated transport systems for...
16.
Ye Z, Gastfriend B, Umlauf B, Lynn D, Shusta E
Pharm Res
. 2022 Feb;
39(7):1523-1534.
PMID: 35169958
The blood-brain barrier (BBB) hinders therapeutic delivery to the central nervous system (CNS), thereby impeding the development of therapies for brain injury and disease. Receptor-mediated transcytosis (RMT) systems are a...
17.
Nishihara H, Perriot S, Gastfriend B, Steinfort M, Cibien C, Soldati S, et al.
Brain
. 2022 Jan;
145(12):4334-4348.
PMID: 35085379
Blood-brain barrier (BBB) breakdown and immune cell infiltration into the CNS are early hallmarks of multiple sclerosis (MS). The mechanisms leading to BBB dysfunction are incompletely understood and generally thought...
18.
Gastfriend B, Nishihara H, Canfield S, Foreman K, Engelhardt B, Palecek S, et al.
Elife
. 2021 Nov;
10.
PMID: 34755601
Endothelial cells (ECs) in the central nervous system (CNS) acquire their specialized blood-brain barrier (BBB) properties in response to extrinsic signals, with Wnt/β-catenin signaling coordinating multiple aspects of this process....
19.
Ding Y, Shusta E, Palecek S
Curr Opin Biomed Eng
. 2021 Oct;
20.
PMID: 34693102
The blood-brain barrier (BBB) regulates the transport of small molecules, proteins, and cells between the bloodstream and the central nervous system (CNS). Brain microvascular endothelial cells work with other resident...
20.
Wang L, Sievert D, Clark A, Lee S, Federman H, Gastfriend B, et al.
Nat Med
. 2021 Jul;
27(9):1600-1606.
PMID: 34244682
Clinical evidence suggests the central nervous system is frequently impacted by SARS-CoV-2 infection, either directly or indirectly, although the mechanisms are unclear. Pericytes are perivascular cells within the brain that...