Edward V Prochownik
Overview
Explore the profile of Edward V Prochownik including associated specialties, affiliations and a list of published articles.
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101
Citations
3014
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Recent Articles
1.
Yao L, Eikelboom J, Macnab A, Yu Z, Cao Y, Wei W, et al.
Adv Biol (Weinh)
. 2025 Feb;
:e2400481.
PMID: 39950362
The prevailing focus of lifespan health research has predominantly centered on "healthy aging". This oversight may hinder the understanding of health across the lifespan, as disorders in earlier stages can...
2.
Chen K, Wang H, Ma B, Knapp J, Henchy C, Lu J, et al.
Am J Pathol
. 2025 Jan;
PMID: 39889823
Hepatoblastoma (HB), the most common pediatric liver cancer, is associated with dysregulated Wnt/β-catenin, Hippo, and/or nuclear factor erythroid 2 ligand 2/nuclear respiratory factor 2 (NFE2L2/NRF2) pathways. In mice, pairwise combinations...
3.
Wu M, Zhou X, Zhou X, Wang G, Zeng Y, Li J, et al.
Cell Rep
. 2024 Nov;
43(11):114962.
PMID: 39522165
Cholesterol metabolism reprogramming plays essential roles in hepatocellular carcinoma (HCC). However, precisely how cholesterol metabolism is dysregulated is not clear. Here, we show that the palmitoyltransferase ZDHHC3 and depalmitoylase ABHD17A...
4.
Zhou X, Chen Z, Yu Y, Li M, Cao Y, Prochownik E, et al.
Adv Sci (Weinh)
. 2024 Sep;
11(43):e2403629.
PMID: 39325640
Certain metabolites in the tumor microenvironment (TME) can alter innate immunity. Here, it is shown how phosphomevalonate kinase (PMVK) allows hepatocellular carcinoma (HCC) cells to overcome the anti-tumor immunity mediated...
5.
Wang H, Ma B, Stevens T, Knapp J, Lu J, Prochownik E
bioRxiv
. 2024 Jul;
PMID: 39071289
The MYC oncoprotein regulates numerous genes involved in cellular processes such as cell cycle and mitochondrial and ribosomal structure and function. This requires heterodimerization with its partner, MAX, and binding...
6.
Zhou X, Wang G, Tian C, Du L, Prochownik E, Li Y
Nat Commun
. 2024 Jul;
15(1):5851.
PMID: 38992029
Tumor cells reprogram their metabolism to produce specialized metabolites that both fuel their own growth and license tumor immune evasion. However, the relationships between these functions remain poorly understood. Here,...
7.
Wang H, Stevens T, Lu J, Roberts A, Vant Land C, Muzumdar R, et al.
Adv Sci (Weinh)
. 2024 Jul;
11(34):e2401593.
PMID: 38976573
The "Mlx" and "Myc" transcription factor networks cross-communicate and share many common gene targets. Myc's activity depends upon its heterodimerization with Max, whereas the Mlx Network requires that the Max-like...
8.
Wang H, Stevens T, Lu J, Roberts A, Vant Land C, Muzumdar R, et al.
bioRxiv
. 2023 Dec;
PMID: 38076995
The "Mlx" and "Myc" Networks share many common gene targets. Just as Myc's activity depends upon its heterodimerization with Max, the Mlx Network requires that the Max-like factor Mlx associate...
9.
Li Y, Karin M, Prochownik E
Explor Target Antitumor Ther
. 2023 Nov;
4(5):1122-1127.
PMID: 38023993
Many human cancers carry missense mutations in or deletions of the tumor protein 53 (TP53) tumor suppressor gene. TP53's product, p53 regulates many biological processes, including cell metabolism. Cholesterol is...
10.
Schmidt A, Monga S, Prochownik E, Goetzman E
Int J Mol Sci
. 2023 Aug;
24(16).
PMID: 37628798
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer deaths globally. Incidence rates are steadily increasing, creating an unmet need for new therapeutic options. Recently, the inhibition of...