Eric C LaCasse
Overview
Explore the profile of Eric C LaCasse including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
34
Citations
1024
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Malone K, Dugas M, Earl N, Alain T, LaCasse E, Beug S
Cell Death Dis
. 2024 Aug;
15(8):592.
PMID: 39147758
Smac mimetic compounds (SMCs) are small molecule drugs that sensitize cancer cells to TNF-α-induced cell death and have multiple immunostimulatory effects through alterations in NF-κB signaling. The combination of SMCs...
2.
Afsahi A, Silvestri C, Moore A, Graham C, Bacchiochi K, St-Jean M, et al.
Front Immunol
. 2023 May;
14:1179827.
PMID: 37138866
Background: The genesis of SMAC mimetic drugs is founded on the observation that many cancers amplify IAP proteins to facilitate their survival, and therefore removal of these pathways would re-sensitize...
3.
Nielsen O, Boye T, Gubatan J, Chakravarti D, Jaquith J, LaCasse E
Pharmacol Ther
. 2023 Apr;
245:108402.
PMID: 37004800
Janus kinase (JAK) inhibitors, also known as jakinibs, are third-generation oral small molecules that have expanded the therapeutic options for the management of chronic inflammatory diseases, including inflammatory bowel disease...
4.
5.
Beug S, Korneluk R, LaCasse E
Mol Cell Oncol
. 2019 Jun;
6(4):1607456.
PMID: 31211235
A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells. In...
6.
Lala-Tabbert N, Lejmi-Mrad R, Timusk K, Fukano M, Holbrook J, St-Jean M, et al.
Skelet Muscle
. 2019 May;
9(1):13.
PMID: 31126323
Background: Skeletal muscle atrophy is a pathological condition that contributes to morbidity in a variety of conditions including denervation, cachexia, and aging. Muscle atrophy is characterized as decreased muscle fiber...
7.
Beug S, Cheung H, Sanda T, St-Jean M, Beauregard C, Mamady H, et al.
Sci Signal
. 2019 Jan;
12(566).
PMID: 30696705
The controlled production and downstream signaling of the inflammatory cytokine tumor necrosis factor-α (TNF-α) are important for immunity and its anticancer effects. Although chronic stimulation with TNF-α is detrimental to...
8.
Beug S, Pichette S, St-Jean M, Holbrook J, Walker D, LaCasse E, et al.
Mol Ther Oncolytics
. 2018 Aug;
10:28-39.
PMID: 30101187
Smac mimetic compounds (SMCs) are anti-cancer drugs that antagonize Inhibitor of Apoptosis proteins, which consequently sensitize cancer cells to death in the presence of proinflammatory ligands such as tumor necrosis...
9.
Beug S, Beauregard C, Healy C, Sanda T, St-Jean M, Chabot J, et al.
Nat Commun
. 2018 Jul;
9:16231.
PMID: 30019697
This corrects the article DOI: 10.1038/ncomms14278.
10.
Moron-Calvente V, Romero-Pinedo S, Toribio-Castello S, Plaza-Diaz J, Abadia-Molina A, Rojas-Barros D, et al.
PLoS One
. 2018 Mar;
13(3):e0193643.
PMID: 29518103
Monocytes and macrophages constitute the first line of defense of the immune system against external pathogens. Macrophages have a highly plastic phenotype depending on environmental conditions; the extremes of this...