Eric C LaCasse
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Explore the profile of Eric C LaCasse including associated specialties, affiliations and a list of published articles.
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34
Citations
1024
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Recent Articles
11.
Beug S, Beauregard C, Healy C, Sanda T, St-Jean M, Chabot J, et al.
Nat Commun
. 2017 Feb;
8.
PMID: 28198370
Small-molecule inhibitor of apoptosis (IAP) antagonists, called Smac mimetic compounds (SMCs), sensitize tumours to TNF-α-induced killing while simultaneously blocking TNF-α growth-promoting activities. SMCs also regulate several immunomodulatory properties within immune...
12.
Dobson C, Naing T, Beug S, Faye M, Chabot J, St-Jean M, et al.
Oncotarget
. 2016 Dec;
8(2):3495-3508.
PMID: 27966453
Rhabdomyosarcoma (RMS), a neoplasm characterized by undifferentiated myoblasts, is the most common soft tissue tumour in children. Therapeutic resistance is common in RMS and is often caused by acquired defects...
13.
Beug S, Conrad D, Alain T, Korneluk R, LaCasse E
Int J Dev Biol
. 2015 Sep;
59(1-3):141-7.
PMID: 26374535
Members of the inhibitor of apoptosis (IAP) family control several critical aspects of innate immunity, cell death, and tumorigenesis. Small molecule antagonists that target specific IAP oncoproteins, primarily cIAP1 and...
14.
LaCasse E, Beug S, Korneluk R
Semin Cell Dev Biol
. 2015 Apr;
39:70-1.
PMID: 25910657
No abstract available.
15.
Pedersen J, LaCasse E, Seidelin J, Coskun M, Nielsen O
Trends Mol Med
. 2014 Oct;
20(11):652-65.
PMID: 25282548
The inhibitor of apoptosis (IAP) family members, notably cIAP1, cIAP2, and XIAP, are critical and universal regulators of tumor necrosis factor (TNF) mediated survival, inflammatory, and death signaling pathways. Furthermore,...
16.
Beug S, LaCasse E, Korneluk R
Oncoimmunology
. 2014 Jul;
3:e28541.
PMID: 25050221
A dual immunotherapy approach employing small-molecule inhibitors of apoptosis (IAP) protein antagonists in combination with innate immune stimuli has proven to be highly synergistic and effective in animal tumor models....
17.
Enwere E, LaCasse E, Adam N, Korneluk R
Front Immunol
. 2014 Feb;
5:34.
PMID: 24550918
Mammalian skeletal muscle maintains a robust regenerative capacity throughout life, largely due to the presence of a stem cell population known as "satellite cells" in the muscle milieu. In normal...
18.
Beug S, Tang V, LaCasse E, Cheung H, Beauregard C, Brun J, et al.
Nat Biotechnol
. 2014 Jan;
32(2):182-90.
PMID: 24463573
Smac mimetic compounds (SMC), a class of drugs that sensitize cells to apoptosis by counteracting the activity of inhibitor of apoptosis (IAP) proteins, have proven safe in phase 1 clinical...
19.
Beug S, Cheung H, LaCasse E, Korneluk R
Trends Immunol
. 2012 Jul;
33(11):535-45.
PMID: 22836014
The inhibitor of apoptosis (IAP) genes are critical regulators of multiple pathways that control cell death, proliferation, and differentiation. Several members of the IAP family regulate innate and adaptive immunity...
20.
LaCasse E
Cancer Lett
. 2012 Jul;
332(2):215-24.
PMID: 22776562
XIAP, the X-linked inhibitor of apoptosis, is the best example of an endogenous cellular suppressor of apoptosis. XIAP is effective because it directly limits the activity of several critical death-inducing...