Emily C Dykhuizen
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Explore the profile of Emily C Dykhuizen including associated specialties, affiliations and a list of published articles.
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41
Citations
995
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Recent Articles
11.
Carcamo S, Nguyen C, Grossi E, Filipescu D, Alpsoy A, Dhiman A, et al.
Cell Rep
. 2022 Apr;
39(1):110637.
PMID: 35385731
ARID2 is the most recurrently mutated SWI/SNF complex member in melanoma; however, its tumor-suppressive mechanisms in the context of the chromatin landscape remain to be elucidated. Here, we model ARID2...
12.
Wang S, Ordonez-Rubiano S, Dhiman A, Jiao G, Strohmier B, Krusemark C, et al.
NAR Cancer
. 2021 Oct;
3(4):zcab039.
PMID: 34617019
Polycomb repressive complexes (PRCs) are a heterogenous collection of dozens, if not hundreds, of protein complexes composed of various combinations of subunits. PRCs are transcriptional repressors important for cell-type specificity...
13.
Wigton E, Mikami Y, McMonigle R, Castellanos C, Wade-Vallance A, Zhou S, et al.
J Exp Med
. 2021 Sep;
218(11).
PMID: 34586363
MicroRNAs (miRNAs, miRs) regulate cell fate decisions by post-transcriptionally tuning networks of mRNA targets. We used miRNA-directed pathway discovery to reveal a regulatory circuit that influences Ig class switch recombination...
14.
Milosevich N, Wilson C, Brown T, Alpsoy A, Wang S, Connelly K, et al.
ChemMedChem
. 2021 Jun;
16(19):3027-3034.
PMID: 34174168
Methyllysine reader proteins bind to methylated lysine residues and alter gene transcription by changing either the compaction state of chromatin or by the recruitment of other multiprotein complexes. The polycomb...
15.
Wang S, Alpsoy A, Sood S, Ordonez-Rubiano S, Dhiman A, Sun Y, et al.
Chembiochem
. 2021 May;
22(13):2335-2344.
PMID: 33950564
Polycomb group (PcG) proteins are epigenetic regulators that facilitate both embryonic development and cancer progression. PcG proteins form Polycomb repressive complexes 1 and 2 (PRC1 and PRC2). PRC2 trimethylates histone...
16.
Alpsoy A, Sood S, Dykhuizen E
Biology (Basel)
. 2021 Apr;
10(4).
PMID: 33801596
In higher order organisms, the genome is assembled into a protein-dense structure called chromatin. Chromatin is spatially organized in the nucleus through hierarchical folding, which is tightly regulated both in...
17.
Alpsoy A, Utturkar S, Carter B, Dhiman A, Torregrosa-Allen S, Currie M, et al.
Cancer Res
. 2020 Dec;
81(4):820-833.
PMID: 33355184
Switch/sucrose-nonfermentable (SWI/SNF) chromatin-remodeling complexes are critical regulators of chromatin dynamics during transcription, DNA replication, and DNA repair. A recently identified SWI/SNF subcomplex termed GLTSCR1/1L-BAF (GBAF; or "noncanonical BAF", ncBAF) uniquely...
18.
Chory E, Kirkland J, Chang C, DAndrea V, Gourisankar S, Dykhuizen E, et al.
ACS Chem Biol
. 2020 May;
15(6):1685-1696.
PMID: 32369697
SWI/SNF (BAF) complexes are a diverse family of ATP-dependent chromatin remodelers produced by combinatorial assembly that are mutated in and thought to contribute to 20% of human cancers and a...
19.
Wang S, Denton K, Hobbs K, Weaver T, McFarlane J, Connelly K, et al.
ACS Chem Biol
. 2019 Nov;
15(1):112-131.
PMID: 31755685
Polycomb repressive complex 1 (PRC1) is critical for mediating gene expression during development. Five chromobox (CBX) homolog proteins, CBX2, CBX4, CBX6, CBX7, and CBX8, are incorporated into PRC1 complexes, where...
20.
Cai B, Kim D, Akhand S, Sun Y, Cassell R, Alpsoy A, et al.
J Am Chem Soc
. 2019 Oct;
141(43):17057-17061.
PMID: 31613623
We report the selection of DNA-encoded small molecule libraries against protein targets within the cytosol and on the surface of live cells. The approach relies on generation of a covalent...