Diana C Hargreaves
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Explore the profile of Diana C Hargreaves including associated specialties, affiliations and a list of published articles.
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36
Citations
3369
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Recent Articles
1.
McRae H, Hargreaves D
Cancer Cell
. 2024 Jul;
42(8):1326-1328.
PMID: 39029465
In Cancer Cell, Bolomsky et al., Duplaquet et al., and He et al. identify cancers that are dependent on the BAF chromatin remodeling complex, specifically IRF4-driven multiple myeloma and POU2F3-subtype...
2.
Liao J, Ho J, Burns M, Dykhuizen E, Hargreaves D
Immunity
. 2024 Jun;
57(8):1780-1795.e6.
PMID: 38843835
Macrophages elicit immune responses to pathogens through induction of inflammatory genes. Here, we examined the role of three variants of the SWI/SNF nucleosome remodeling complex-cBAF, ncBAF, and PBAF-in the macrophage...
3.
Wu Z, Pope S, Ahmed N, Leung D, Hajjar S, Yue Q, et al.
bioRxiv
. 2024 May;
PMID: 38798655
Inflammation is an essential defense response but operates at the cost of normal functions. Whether and how the negative impact of inflammation is monitored remains largely unknown. Acidification of the...
4.
Maxwell M, Hom-Tedla M, Yi J, Li S, Rivera S, Yu J, et al.
Cell
. 2024 May;
187(13):3390-3408.e19.
PMID: 38754421
Clinical trials have identified ARID1A mutations as enriched among patients who respond favorably to immune checkpoint blockade (ICB) in several solid tumor types independent of microsatellite instability. We show that...
5.
6.
McDonald B, Chick B, Hargreaves D, Kaech S
Yale J Biol Med
. 2024 Jan;
96(4):467-473.
PMID: 38161581
T cells undergo extensive chromatin remodeling over several days following stimulation through the T cell receptor. However, the kinetics and gene loci targeted by early remodeling events within the first...
7.
8.
Mangalhara K, Varanasi S, Johnson M, Burns M, Rojas G, Esparza Molto P, et al.
Science
. 2023 Sep;
381(6664):1316-1323.
PMID: 37733872
Although tumor growth requires the mitochondrial electron transport chain (ETC), the relative contribution of complex I (CI) and complex II (CII), the gatekeepers for initiating electron flow, remains unclear. In...
9.
McDonald B, Chick B, Ahmed N, Burns M, Ma S, Casillas E, et al.
Immunity
. 2023 Jun;
56(6):1303-1319.e5.
PMID: 37315534
CD8 T cells provide host protection against pathogens by differentiating into distinct effector and memory cell subsets, but how chromatin is site-specifically remodeled during their differentiation is unclear. Due to...
10.
Multi-Omics Atlas-Assisted Discovery of Transcription Factors for Selective T Cell State Programming
Chung H, Liu C, Jambor A, Riesenberg B, Sun M, Casillas E, et al.
bioRxiv
. 2023 Jan;
PMID: 36711632
Transcription factors (TFs) regulate the differentiation of T cells into diverse states with distinct functionalities. To precisely program desired T cell states in viral infections and cancers, we generated a...