Emily C Dykhuizen
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Explore the profile of Emily C Dykhuizen including associated specialties, affiliations and a list of published articles.
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Articles
41
Citations
995
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Recent Articles
1.
Tinsley S, Chianis E, Shelley R, Mall G, Dhiman A, Baral G, et al.
Oncogene
. 2024 Oct;
43(50):3673-3687.
PMID: 39443726
Oncogenic mutations in KRAS are present in ~95% of patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) and are considered the initiating event of pancreatic intraepithelial neoplasia (PanIN) precursor lesions. While...
2.
Cornejo K, Venegas A, Sono M, Door M, Gutierrez-Ruiz B, Karabedian L, et al.
Cell Rep
. 2024 Oct;
43(11):114877.
PMID: 39412992
Signal-dependent RNA polymerase II (RNA Pol II) productive elongation is an integral component of gene transcription, including that of immediate early genes (IEGs) induced by neuronal activity. However, it remains...
3.
Liao J, Ho J, Burns M, Dykhuizen E, Hargreaves D
Immunity
. 2024 Jun;
57(8):1780-1795.e6.
PMID: 38843835
Macrophages elicit immune responses to pathogens through induction of inflammatory genes. Here, we examined the role of three variants of the SWI/SNF nucleosome remodeling complex-cBAF, ncBAF, and PBAF-in the macrophage...
4.
Tinsley S, Shelley R, Mall G, Chianis E, Dhiman A, Baral G, et al.
bioRxiv
. 2024 Jun;
PMID: 38826439
Oncogenic mutations in KRAS are present in approximately 95% of patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) and are considered the initiating event of pancreatic intraepithelial neoplasia (PanIN) precursor lesions....
5.
Maxwell M, Hom-Tedla M, Yi J, Li S, Rivera S, Yu J, et al.
Cell
. 2024 May;
187(13):3390-3408.e19.
PMID: 38754421
Clinical trials have identified ARID1A mutations as enriched among patients who respond favorably to immune checkpoint blockade (ICB) in several solid tumor types independent of microsatellite instability. We show that...
6.
Bursch K, Goetz C, Jiao G, Nunez R, Olp M, Dhiman A, et al.
J Biol Chem
. 2024 Mar;
300(4):107146.
PMID: 38460939
The polybromo, brahma-related gene 1-associated factors (PBAF) chromatin remodeling complex subunit polybromo-1 (PBRM1) contains six bromodomains that recognize and bind acetylated lysine residues on histone tails and other nuclear proteins....
7.
Cornejo K, Venegas A, Sono M, Door M, Gutierrez-Ruiz B, Karabedian L, et al.
bioRxiv
. 2024 Jan;
PMID: 38234780
Signal-dependent RNA Polymerase II (Pol2) productive elongation is an integral component of gene transcription, including those of immediate early genes (IEGs) induced by neuronal activity. However, it remains unclear how...
8.
Ordonez-Rubiano S, Maschinot C, Wang S, Sood S, Baracaldo-Lancheros L, Strohmier B, et al.
J Med Chem
. 2023 Aug;
66(16):11250-11270.
PMID: 37552884
Bromodomain-containing proteins are readers of acetylated lysine and play important roles in cancer. Bromodomain-containing protein 7 (BRD7) is implicated in multiple malignancies; however, there are no selective chemical probes to...
9.
De Silva S, Dhiman A, Sood S, Mercedes K, Simmons W, Henen M, et al.
Nucleic Acids Res
. 2023 Feb;
51(8):3631-3649.
PMID: 36808431
PBRM1 is a subunit of the PBAF chromatin remodeling complex, which is mutated in 40-50% of clear cell renal cell carcinoma patients. It is thought to largely function as a...
10.
Shishodia S, Nunez R, Strohmier B, Bursch K, Goetz C, Olp M, et al.
J Med Chem
. 2022 Oct;
65(20):13714-13735.
PMID: 36227159
PBRM1 is a subunit of the PBAF chromatin remodeling complex that uniquely contains six bromodomains. PBRM1 can operate as a tumor suppressor or tumor promoter. PBRM1 is a tumor promoter...