Emanuel F Petricoin 3rd
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Explore the profile of Emanuel F Petricoin 3rd including associated specialties, affiliations and a list of published articles.
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150
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4993
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Recent Articles
1.
Berezovsky A, Nuga O, Datta I, Bergman K, Sabedot T, Gurdziel K, et al.
PLoS One
. 2025 Feb;
20(2):e0315171.
PMID: 39919036
Glioblastoma (GBM) tumors exhibit extensive genomic, epigenomic, and transcriptional diversity, with significant intratumoral heterogeneity, complicating standard treatment approaches involving radiation (RT) and the DNA-alkylating agent temozolomide (TMZ). In this study,...
2.
Klomp J, Diehl J, Klomp J, Edwards A, Yang R, Morales A, et al.
Science
. 2024 Jun;
384(6700):eadk0850.
PMID: 38843329
To delineate the mechanisms by which the ERK1 and ERK2 mitogen-activated protein kinases support mutant KRAS-driven cancer growth, we determined the ERK-dependent phosphoproteome in KRAS-mutant pancreatic cancer. We determined that...
3.
Nussbaum D, Martz C, Waters A, Barrera A, Liu A, Rutter J, et al.
NPJ Precis Oncol
. 2024 May;
8(1):124.
PMID: 38822082
Acquired resistance remains a major challenge for therapies targeting oncogene activated pathways. KRAS is the most frequently mutated oncogene in human cancers, yet strategies targeting its downstream signaling kinases have...
4.
Delgado-Coka L, Horowitz M, Torrente-Goncalves M, Roa-Pena L, Leiton C, Hasan M, et al.
J Transl Med
. 2024 May;
22(1):443.
PMID: 38730319
Background: The immune microenvironment impacts tumor growth, invasion, metastasis, and patient survival and may provide opportunities for therapeutic intervention in pancreatic ductal adenocarcinoma (PDAC). Although never studied as a potential...
5.
Delgado-Coka L, Roa-Pena L, Babu S, Horowitz M, Petricoin 3rd E, Matrisian L, et al.
Am J Clin Pathol
. 2024 Apr;
162(3):314-326.
PMID: 38642081
Objectives: To determine the role of keratin 17 (K17) as a predictive biomarker for response to chemotherapy by defining thresholds of K17 expression based on immunohistochemical tests that could be...
6.
Grit J, McGee L, Tovar E, Essenburg C, Wolfrum E, Beddows I, et al.
Oncogene
. 2024 Mar;
43(19):1411-1430.
PMID: 38480916
Malignant peripheral nerve sheath tumors (MPNSTs) are chemotherapy resistant sarcomas that are a leading cause of death in neurofibromatosis type 1 (NF1). Although NF1-related MPNSTs derive from neural crest cell...
7.
Baldelli E, Mandarano M, Bellezza G, Petricoin 3rd E, Pierobon M
Cell Rep Methods
. 2022 Sep;
2(8):100271.
PMID: 36046628
Clonal evolution and lineage plasticity are key contributors to tumor heterogeneity and response to treatment in cancer. However, capturing signal transduction events in coexisting clones remains challenging from a technical...
8.
Huynh M, Hobbs G, Schaefer A, Pierobon M, Carey L, Diehl J, et al.
Sci Signal
. 2022 Aug;
15(746):eabn2694.
PMID: 35944066
Missense mutations at the three hotspots in the guanosine triphosphatase (GTPase) RAS-Gly, Gly, and Gln (commonly known as G12, G13, and Q61, respectively)-occur differentially among the three RAS isoforms. Q61...
9.
Klomp J, Lee Y, Goodwin C, Papke B, Klomp J, Waters A, et al.
Cell Rep
. 2021 Dec;
37(9):110060.
PMID: 34852220
We apply genetic screens to delineate modulators of KRAS mutant pancreatic ductal adenocarcinoma (PDAC) sensitivity to ERK inhibitor treatment, and we identify components of the ATR-CHK1 DNA damage repair (DDR)...
10.
Diehl J, Klomp J, Snare K, Hibshman P, Blake D, Kaiser Z, et al.
J Biol Chem
. 2021 Oct;
297(5):101335.
PMID: 34688654
Oncogenic KRAS drives cancer growth by activating diverse signaling networks, not all of which have been fully delineated. We set out to establish a system-wide profile of the KRAS-regulated kinase...