Ellis Jaffray
Overview
Explore the profile of Ellis Jaffray including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
23
Citations
922
Followers
0
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Recent Articles
1.
Rojas-Fernandez A, Plechanovova A, Hattersley N, Jaffray E, Tatham M, Hay R
Mol Cell
. 2014 Mar;
53(6):880-92.
PMID: 24656128
Dimeric RING E3 ligases interact with protein substrates and conformationally restrain the ubiquitin-E2-conjugating enzyme thioester complex such that it is primed for catalysis. RNF4 is an E3 ligase containing an...
2.
Berscheminski J, Wimmer P, Brun J, Ip W, Groitl P, Horlacher T, et al.
J Virol
. 2014 Mar;
88(11):6076-92.
PMID: 24623443
Unlabelled: Promyelocytic leukemia nuclear bodies (PML-NBs) are nuclear structures that accumulate intrinsic host factors to restrict viral infections. To ensure viral replication, these must be limited by expression of viral...
3.
Citro S, Jaffray E, Hay R, Seiser C, Chiocca S
J Mol Cell Biol
. 2013 Sep;
5(6):416-27.
PMID: 24068740
Histone deacetylase 1 (HDAC1) is an essential epigenetic regulator belonging to a highly conserved family of deacetylases. Increased HDAC1 activity and expression often correlates with neoplastic transformation. Here we show...
4.
Zhou W, Hannoun Z, Jaffray E, Medine C, Black J, Greenhough S, et al.
J Cell Sci
. 2012 Apr;
125(Pt 15):3630-5.
PMID: 22505616
The coordination of signalling pathways within the cell is vital for normal human development and post-natal tissue homeostasis. Gene expression and function is therefore tightly controlled at a number of...
5.
Hannoun Z, Greenhough S, Jaffray E, Hay R, Hay D
Toxicology
. 2010 Aug;
278(3):288-93.
PMID: 20674646
Post-translational modifications (PTMs) are chemical alterations to a protein following translation, regulating stability and function. Reversible phosphorylation is an example of an important and well studied PTM involved in a...
6.
Miles W, Jaffray E, Campbell S, Takeda S, Bayston L, Basu S, et al.
Genes Dev
. 2008 Sep;
22(18):2578-90.
PMID: 18794353
Morphogens are secreted signaling molecules that form concentration gradients and control cell fate in developing tissues. During development, it is essential that morphogen range is strictly regulated in order for...
7.
Agostinho M, Santos V, Ferreira F, Costa R, Cardoso J, Pinheiro I, et al.
Cancer Res
. 2008 Apr;
68(7):2409-18.
PMID: 18381449
Type 2 topoisomerases, in particular the alpha isoform in human cells, play a key role in cohesion and sister chromatid separation during mitosis. These enzymes are thus vital for cycling...
8.
Watson M, Wallace K, Gieling R, Manas D, Jaffray E, Hay R, et al.
J Hepatol
. 2008 Feb;
48(4):589-97.
PMID: 18279996
Background/aims: Hepatic myofibroblast activation during injury causes deposition of extracellular matrix within the liver and promotes development of fibrosis. Hepatic myofibroblast apoptosis is associated with remodelling of fibrotic extracellular matrix...
9.
Tillmanns S, Otto C, Jaffray E, du Roure C, Bakri Y, Vanhille L, et al.
Mol Cell Biol
. 2007 Jun;
27(15):5554-64.
PMID: 17548468
During the execution of differentiation programs, lineage-specific transcription factors are in competition with antagonistic factors that drive progenitor proliferation. Thus, the myeloid transcription factor MafB promotes macrophage differentiation of myeloid...
10.
Cooper H, Tatham M, Jaffray E, Heath J, Lam T, Marshall A, et al.
Anal Chem
. 2005 Oct;
77(19):6310-9.
PMID: 16194093
The attachment of the ubiquitin-like protein SUMO to target proteins is involved in a number of important cellular processes. Typically, SUMO modification occurs on lysine residues within the consensus sequence...