Ellis Jaffray
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Explore the profile of Ellis Jaffray including associated specialties, affiliations and a list of published articles.
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23
Citations
922
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Recent Articles
11.
Desterro J, Keegan L, Jaffray E, Hay R, OConnell M, Carmo-Fonseca M
Mol Biol Cell
. 2005 Aug;
16(11):5115-26.
PMID: 16120648
We identify ADAR1, an RNA-editing enzyme with transient nucleolar localization, as a novel substrate for sumoylation. We show that ADAR1 colocalizes with SUMO-1 in a subnucleolar region that is distinct...
12.
Hofmann T, Jaffray E, Stollberg N, Hay R, Will H
J Biol Chem
. 2005 Jun;
280(32):29224-32.
PMID: 15958389
Homeodomain-interacting protein kinase 2 (HIPK2) is involved in transcriptional regulation, growth suppression, and apoptosis. Previous reports showed that HIPK2 can signal cell death via p53, and independently of p53 by...
13.
Degerny C, Monte D, Beaudoin C, Jaffray E, Portois L, Hay R, et al.
J Biol Chem
. 2005 Apr;
280(26):24330-8.
PMID: 15857832
A variety of transcription factors are post-translationally modified by SUMO, a 97-residue ubiquitin-like protein bound covalently to the targeted lysine. Here we describe SUMO modification of the Ets family member...
14.
Boyer-Guittaut M, Birsoy K, Potel C, Elliott G, Jaffray E, Desterro J, et al.
J Biol Chem
. 2005 Jan;
280(11):9937-45.
PMID: 15637059
The TFIID complex is composed of the TATA-binding protein (TBP) and TBP-associated factors (TAFs) and is the only component of the general RNA polymerase II (RNAP II) transcription machinery with...
15.
Ghioni P, DAlessandra Y, Mansueto G, Jaffray E, Hay R, La Mantia G, et al.
Cell Cycle
. 2004 Dec;
4(1):183-90.
PMID: 15611636
Post-translational modification of proteins by the ubiquitin-like molecule SUMO-1 regulates their stability and activity with crucial implications for many cellular processes. Here we show that p63alpha, but not p63beta and...
16.
Tatham M, Kim S, Jaffray E, Song J, Chen Y, Hay R
Nat Struct Mol Biol
. 2004 Dec;
12(1):67-74.
PMID: 15608651
The conjugation of small ubiquitin-like modifiers SUMO-1, SUMO-2 and SUMO-3 onto target proteins requires the concerted action of the specific E1-activating enzyme SAE1/SAE2, the E2-conjugating enzyme Ubc9, and an E3-like...
17.
Fujihara S, Jaffray E, Farrow S, Rossi A, Haslett C, Hay R
Biochem Biophys Res Commun
. 2004 Dec;
326(3):632-7.
PMID: 15596146
An 11 amino acid HIV-TAT peptide can deliver target proteins into a variety of cells in a receptor-independent manner. To generate a highly specific inhibitor of the transcription factor NF-kappa...
18.
Cooper H, Heath J, Jaffray E, Hay R, Lam T, Marshall A
Anal Chem
. 2004 Dec;
76(23):6982-8.
PMID: 15571350
Structural elucidation of posttranslationally modified peptides and proteins is of key importance in the understanding of an array of biological processes. Ubiquitination is a reversible modification that regulates many cellular...
19.
Vertegaal A, Ogg S, Jaffray E, Rodriguez M, Hay R, Andersen J, et al.
J Biol Chem
. 2004 Jun;
279(32):33791-8.
PMID: 15175327
The SUMO family in vertebrates includes at least three distinct proteins (SUMO-1, -2, and -3) that are added as post-translational modifications to target proteins. A considerable number of SUMO-1 target...
20.
Yang S, Jaffray E, Senthinathan B, Hay R, Sharrocks A
Cell Cycle
. 2003 Sep;
2(6):528-30.
PMID: 14504467
SUMO modification of proteins is being increasingly linked with transcriptional repression. We recently demonstrated that SUMO modification also downregulates the transcriptional activity of the ETS-domain transcription factor Elk-1. However, as...