Ellen A Robey
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Explore the profile of Ellen A Robey including associated specialties, affiliations and a list of published articles.
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75
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2618
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Recent Articles
1.
Park C, Guan J, Rhee P, Gonzalez F, Lee H, Park J, et al.
Elife
. 2024 Aug;
13.
PMID: 39158947
The fate of developing T cells is determined by the strength of T cell receptor (TCR) signal they receive in the thymus. This process is finely regulated through the tuning...
2.
Adjusting to self in the thymus: CD4 versus CD8 lineage commitment and regulatory T cell development
Baldwin I, Robey E
J Exp Med
. 2024 Jul;
221(10).
PMID: 38980291
During thymic development, thymocytes adjust their TCR response based on the strength of their reactivity to self-peptide MHC complexes. This tuning process allows thymocytes with a range of self-reactivities to...
3.
Steier Z, Kim E, Aylard D, Robey E
Annu Rev Immunol
. 2024 Jan;
42(1):235-258.
PMID: 38271641
The choice of developing thymocytes to become CD8+ cytotoxic or CD4+ helper T cells has been intensely studied, but many of the underlying mechanisms remain to be elucidated. Recent multiomics...
4.
Guan J, Peske J, Manoharan Valerio M, Park C, Robey E, Sadegh-Nasseri S
Elife
. 2023 Dec;
12.
PMID: 38127067
Intestinal intraepithelial lymphocytes (IELs) are characterized by an unusual phenotype and developmental pathway, yet their specific ligands and functions remain largely unknown. Here by analysis of QFL T cells, a...
5.
Manoharan Valerio M, Arana K, Guan J, Chan S, Yang X, Kurd N, et al.
Front Immunol
. 2023 Nov;
14:1250316.
PMID: 38022509
MHC-E restricted CD8 T cells show promise in vaccine settings, but their development and specificity remain poorly understood. Here we focus on a CD8 T cell population reactive to a...
6.
Steier Z, Aylard D, McIntyre L, Baldwin I, Kim E, Lutes L, et al.
Nat Immunol
. 2023 Aug;
24(9):1579-1590.
PMID: 37580604
The development of CD4 T cells and CD8 T cells in the thymus is critical to adaptive immunity and is widely studied as a model of lineage commitment. Recognition of...
7.
Geiger K, Manoharan M, Coombs R, Arana K, Park C, Lee A, et al.
Cell Rep
. 2023 Mar;
42(4):112317.
PMID: 36995940
The endoplasmic reticulum aminopeptidase associated with antigen processing (ERAAP) plays a crucial role in shaping the peptide-major histocompatibility complex (MHC) class I repertoire and maintaining immune surveillance. While murine cytomegalovirus...
8.
Guan J, Peske J, Manoharan Valerio M, Park C, Robey E, Sadegh-Nasseri S
bioRxiv
. 2023 Mar;
PMID: 36909616
Intestinal intraepithelial lymphocytes (IELs) are characterized by an unusual phenotype and developmental pathway, yet their specific ligands and functions remain largely unknown. Here by analysis of QFL T cells, a...
9.
Zhou T, Hsu H, Tu Y, Cheng H, Lin C, Chen N, et al.
Elife
. 2022 Nov;
11.
PMID: 36449334
Tissue-resident macrophages are essential to protect from pathogen invasion and maintain organ homeostasis. The ability of thymic macrophages to engulf apoptotic thymocytes is well appreciated, but little is known about...
10.
McIntyre L, Lutes L, Robey E
Methods Mol Biol
. 2022 Nov;
2580:233-247.
PMID: 36374461
T cell development occurs in the thymus and is coordinated temporally and spatially within the highly complex thymic microenvironment. Therefore, T cell selection and maturation events cannot be fully recapitulated...