Marian C Okondo
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Explore the profile of Marian C Okondo including associated specialties, affiliations and a list of published articles.
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8
Citations
1109
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Recent Articles
1.
Johnson D, Okondo M, Orth E, Rao S, Huang H, Ball D, et al.
Cell Death Dis
. 2020 Aug;
11(8):628.
PMID: 32796818
Canonical inflammasomes are innate immune signaling platforms that are formed in response to intracellular pathogen-associated signals and trigger caspase-1-dependent pyroptosis. Inflammasome formation and signaling is thought to mainly occur in...
2.
Gai K, Okondo M, Rao S, Chui A, Ball D, Johnson D, et al.
Cell Death Dis
. 2019 Aug;
10(8):587.
PMID: 31383852
Intracellular pathogenic structures or activities stimulate the formation of inflammasomes, which recruit and activate caspase-1 and trigger an inflammatory form of cell death called pyroptosis. The well-characterized mammalian inflammasome sensor...
3.
Chui A, Okondo M, Rao S, Gai K, Griswold A, Johnson D, et al.
Science
. 2019 Mar;
364(6435):82-85.
PMID: 30872531
Intracellular pathogens and danger signals trigger the formation of inflammasomes, which activate inflammatory caspases and induce pyroptosis. The anthrax lethal factor metalloprotease and small-molecule DPP8/9 inhibitors both activate the NLRP1B...
4.
Johnson D, Taabazuing C, Okondo M, Chui A, Rao S, Brown F, et al.
Nat Med
. 2018 Jul;
24(8):1151-1156.
PMID: 29967349
Small-molecule inhibitors of the serine dipeptidases DPP8 and DPP9 (DPP8/9) induce a lytic form of cell death called pyroptosis in mouse and human monocytes and macrophages. In mouse myeloid cells,...
5.
Okondo M, Rao S, Taabazuing C, Chui A, Poplawski S, Johnson D, et al.
Cell Chem Biol
. 2018 Feb;
25(3):262-267.e5.
PMID: 29396289
Val-boroPro (PT-100, Talabostat) induces powerful anti-tumor immune responses in syngeneic cancer models, but its mechanism of action has not yet been established. Val-boroPro is a non-selective inhibitor of post-proline-cleaving serine...
6.
Taabazuing C, Okondo M, Bachovchin D
Cell Chem Biol
. 2017 Apr;
24(4):507-514.e4.
PMID: 28392147
Pyroptosis is a lytic form of programmed cell death mediated by the inflammatory caspase-1, -4, and -5. We recently discovered that small-molecule inhibitors of the serine peptidases DPP8 and DPP9 ...
7.
Keckesova Z, Liu Donaher J, De Cock J, Freinkman E, Lingrell S, Bachovchin D, et al.
Nature
. 2017 Mar;
543(7647):681-686.
PMID: 28329758
Post-mitotic, differentiated cells exhibit a variety of characteristics that contrast with those of actively growing neoplastic cells, such as the expression of cell-cycle inhibitors and differentiation factors. We hypothesized that...
8.
Okondo M, Johnson D, Sridharan R, Go E, Chui A, Wang M, et al.
Nat Chem Biol
. 2016 Nov;
13(1):46-53.
PMID: 27820798
Val-boroPro (Talabostat, PT-100), a nonselective inhibitor of post-proline cleaving serine proteases, stimulates mammalian immune systems through an unknown mechanism of action. Despite this lack of mechanistic understanding, Val-boroPro has attracted...