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Elizabete S Candido

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Citations 171
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Recent Articles
1.
Rezende S, Chan L, Oshiro K, Buccini D, Leal A, Ribeiro C, et al.
Biochim Biophys Acta Gen Subj . 2024 Aug; 1868(11):130693. PMID: 39147109
Background: Resistant infectious diseases caused by gram-negative bacteria are among the most serious worldwide health problems. Antimicrobial peptides (AMPs) have been explored as promising antibacterial, antibiofilm, and anti-infective candidates to...
2.
Cardoso M, Chan L, Candido E, Buccini D, Rezende S, Torres M, et al.
Chem Sci . 2022 Sep; 13(32):9410-9424. PMID: 36093022
Structural diversity drives multiple biological activities and mechanisms of action in linear peptides. Here we describe an unusual N-capping asparagine-lysine-proline (NKP) motif that confers a hybrid multifunctional scaffold to a...
3.
Cardoso M, Orozco R, Rezende S, Rodrigues G, Oshiro K, Candido E, et al.
Front Microbiol . 2020 Feb; 10:3097. PMID: 32038544
Antimicrobial peptides (AMPs), especially antibacterial peptides, have been widely investigated as potential alternatives to antibiotic-based therapies. Indeed, naturally occurring and synthetic AMPs have shown promising results against a series of...
4.
de Barros E, Goncalves R, Cardoso M, Santos N, Franco O, Candido E
Front Pharmacol . 2019 Dec; 10:1415. PMID: 31849667
Bioactive small molecules isolated from animals, plants, fungi and bacteria, including natural antimicrobial peptides, have shown great therapeutic potential worldwide. Among these peptides, snake venom cathelicidins are being widely exploited,...
5.
Oshiro K, Candido E, Chan L, Torres M, Monges B, Rodrigues S, et al.
J Med Chem . 2019 Aug; 62(17):8140-8151. PMID: 31411881
Diverse peptides have been evaluated for their activity against pathogenic microorganisms. Here, five mastoparan variants were designed based on mastoparan-L, among which two (R1 and R4) were selected for in-depth...
6.
Candido E, Cardoso M, Chan L, Torres M, Oshiro K, Porto W, et al.
ACS Infect Dis . 2019 Apr; 5(7):1081-1086. PMID: 31016969
Bacterial biofilms and associated infections represent one of the biggest challenges in the clinic, and as an alternative to counter bacterial infections, antimicrobial peptides have attracted great attention in the...
7.
Cardoso M, Candido E, Chan L, Torres M, Oshiro K, Rezende S, et al.
ACS Infect Dis . 2018 Oct; 4(12):1727-1736. PMID: 30346140
Computer-aided screening of antimicrobial peptides (AMPs) is a promising approach for discovering novel therapies against multidrug-resistant bacterial infections. Here, we functionally and structurally characterized an Escherichia coli-derived AMP (EcDBS1R5) previously...
8.
Cardoso M, de Almeida K, Candido E, Fernandes G, Dias S, de Alencar S, et al.
Microbiology (Reading) . 2018 Oct; 164(11):1383-1393. PMID: 30277857
Antimicrobial peptides (AMPs) have attracted considerable attention because of their multiple and complex mechanisms of action toward resistant bacteria. However, reports have increasingly highlighted how bacteria can escape AMP administration....
9.
Junior N, Cardoso M, Candido E, van den Broek D, de Lange N, Velikova N, et al.
Sci Rep . 2018 Jul; 8(1):11127. PMID: 30042491
In order to study how acidic pro-peptides inhibit the antimicrobial activity of antimicrobial peptides, we introduce a simple model system, consisting of a 19 amino-acid long antimicrobial peptide, and an...
10.
Cardoso M, Oshiro K, Rezende S, Candido E, Franco O
Adv Protein Chem Struct Biol . 2018 Apr; 112:359-384. PMID: 29680241
Antimicrobial peptides (AMPs) have been widely isolated from most organisms in nature. This class of antimicrobials may undergo changes in their sequence for improved physicochemical properties, including charge, hydrophobicity, and...