David J Craik
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Explore the profile of David J Craik including associated specialties, affiliations and a list of published articles.
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560
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12541
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Recent Articles
1.
Troeira Henriques S, Lawrence N, Kan M, Malins L, Craik D
Biochemistry
. 2025 Mar;
PMID: 40082248
Peptides that have a head-to-tail cyclic backbone tend to be more stable than linear peptides, as do peptides that contain one or more cross-linking disulfide bond. Some of these cyclic...
2.
Palombi I, White A, Koda Y, Craik D, Lawrence N, Malins L
Chem Biol Drug Des
. 2025 Jan;
105(1):e70051.
PMID: 39834140
Drug targeting strategies, such as peptide-drug conjugates (PDCs), have arisen to combat the issue of off-target toxicity that is commonly associated with chemotherapeutic small molecule drugs. Here we investigated the...
3.
de Veer S, Craik D, Rehm F
J Am Chem Soc
. 2024 Dec;
147(1):557-565.
PMID: 39714948
Transpeptidases are specialized enzymes that have evolved for site-selective modification of peptides and proteins at their backbone termini. Approaches for adapting transpeptidases to catalyze side chain modifications are substantially more...
4.
Cardoso M, de Lima L, Pires A, Maximiano M, Harvey P, Freitas C, et al.
ACS Omega
. 2024 Nov;
9(45):45297-45308.
PMID: 39554447
Defensins are present in many organisms and are divided into two evolutionary groups, termed - and -defensins. -defensins have only recently been reported in bacteria, and knowledge of these defensins...
5.
Gare C, Palombi I, White A, Chavchich M, Edstein M, Lock A, et al.
ChemMedChem
. 2024 Oct;
20(2):e202400637.
PMID: 39379289
The devastating impact of malaria includes significant mortality and illness worldwide. Increasing resistance of the causative parasite, Plasmodium, to existing antimalarial drugs underscores a need for additional compounds with distinct...
6.
Yayci A, Huang Y, Harvey P, Craik D
Chembiochem
. 2024 Sep;
26(4):e202400591.
PMID: 39239927
This study describes the design, production, and characterization of a novel conditional intein system for the recombinant production of cyclic peptides. The system is based on two key features: (1)...
7.
Biswas B, Huang Y, Craik D, Wang C
Chem Sci
. 2024 Aug;
15(33):13130-13147.
PMID: 39183924
Human kinases are recognized as one of the most important drug targets associated with cancer. There are >80 FDA-approved kinase inhibitors to date, most of which work by inhibiting ATP...
8.
Rezende S, Chan L, Oshiro K, Buccini D, Leal A, Ribeiro C, et al.
Biochim Biophys Acta Gen Subj
. 2024 Aug;
1868(11):130693.
PMID: 39147109
Background: Resistant infectious diseases caused by gram-negative bacteria are among the most serious worldwide health problems. Antimicrobial peptides (AMPs) have been explored as promising antibacterial, antibiofilm, and anti-infective candidates to...
9.
Rehm F, Tyler T, Zhou Y, Huang Y, Wang C, Lawrence N, et al.
Nat Chem
. 2024 Aug;
16(9):1565.
PMID: 39138347
No abstract available.
10.
Gilding E, Jackson M, Nguyen L, Hamilton B, Farquharson K, Ho W, et al.
Nat Commun
. 2024 Aug;
15(1):6565.
PMID: 39095373
The legume albumin-1 gene family, arising after nodulation, encodes linear a- and b-chain peptides for nutrient storage and defense. Intriguingly, in one prominent legume, Clitoria ternatea, the b-chains are replaced...