Elina Jarho
Overview
Explore the profile of Elina Jarho including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
387
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Recent Articles
1.
Rahnasto-Rilla M, Tyni J, Huovinen M, Jarho E, Kulikowicz T, Ravichandran S, et al.
Sci Rep
. 2018 Mar;
8(1):4163.
PMID: 29515203
Flavonoids are polyphenolic secondary metabolites synthesized by plants and fungus with various pharmacological effects. Due to their plethora of biological activities, they have been studied extensively in drug development. They...
2.
Carafa V, Rotili D, Forgione M, Cuomo F, Serretiello E, Hailu G, et al.
Clin Epigenetics
. 2016 May;
8:61.
PMID: 27226812
Sirtuins are NAD(+)-dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair, cell...
3.
Rahnasto-Rilla M, Kokkola T, Jarho E, Lahtela-Kakkonen M, Moaddel R
Chembiochem
. 2015 Nov;
17(1):77-81.
PMID: 26607666
Sirtuin 6 (SIRT6) is an NAD+-dependent histone deacetylase enzyme that is involved in multiple molecular pathways related to aging. Initially, it was reported that SIRT6 selectively deacetylated H3K9Ac and H3K56Ac;...
4.
Kokkonen P, Kokkola T, Suuronen T, Poso A, Jarho E, Lahtela-Kakkonen M
Eur J Pharm Sci
. 2015 May;
76:27-32.
PMID: 25936698
Sirtuins (SIRT1-SIRT7) are NAD dependent deacetylases and intriguing drug targets in for example neurodegenerative diseases and cancer. Virtual screening has been shown to be a fast and efficient method of...
5.
Kokkonen P, Rahnasto-Rilla M, Mellini P, Jarho E, Lahtela-Kakkonen M, Kokkola T
Eur J Pharm Sci
. 2014 Jul;
63:71-6.
PMID: 25004411
SIRT6 is a modulator of chromatin structure having an important role in healthy ageing, and there is a crucial need to find specific modulators for it. Therefore, the activity of...
6.
Kokkonen P, Rahnasto-Rilla M, Kiviranta P, Huhtiniemi T, Laitinen T, Poso A, et al.
ACS Med Chem Lett
. 2014 Jun;
3(12):969-74.
PMID: 24900419
SIRT6 belongs to the family of histone deacetylases (class III), but it also has mono-ADP-ribosyltransferase activity. SIRT6 is a nuclear sirtuin that has been associated with aging, cellular protection, and...
7.
Kokkonen P, Mellini P, Nyrhila O, Rahnasto-Rilla M, Suuronen T, Kiviranta P, et al.
Eur J Pharm Sci
. 2014 Apr;
59:12-9.
PMID: 24747578
Sirtuin 1 (SIRT1) is the most studied human sirtuin and it catalyzes the deacetylation reaction of acetylated lysine residues of its target proteins, for example histones. It is a promising...
8.
Christodoulou M, Sacchetti A, Ronchetti V, Caufin S, Silvani A, Lesma G, et al.
Bioorg Med Chem
. 2013 Oct;
21(22):6920-8.
PMID: 24103429
This paper reports the synthesis of a series of evodiamine derivatives. We assayed the ability to inhibit cell growth on three human tumour cell lines (H460, MCF-7 and HepG2) and...
9.
Salo H, Laitinen T, Poso A, Jarho E, Lahtela-Kakkonen M
Bioorg Med Chem Lett
. 2013 Apr;
23(10):2990-5.
PMID: 23562596
SIRT3 is a member of the sirtuin family of histone deacetylases. It is a mitochondrial protein, which has an important role in metabolic homeostasis but it may also act as...
10.
Huhtiniemi T, Salo H, Suuronen T, Poso A, Salminen A, Leppanen J, et al.
J Med Chem
. 2011 Sep;
54(19):6456-68.
PMID: 21895016
The lack of substrate-bound crystal structures of SIRT1 and SIRT2 complicates the drug design for these targets. In this work, we aim to study whether SIRT3 could serve as a...