Piia Kokkonen
Overview
Explore the profile of Piia Kokkonen including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
382
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Recent Articles
1.
Horak M, Fairweather D, Kokkonen P, Bednar D, Bienertova-Vasku J
Heart Fail Rev
. 2022 Jul;
27(6):2251-2265.
PMID: 35867287
Cardiovascular diseases (CVDs) are a group of disorders affecting the heart and blood vessels and a leading cause of death worldwide. Thus, there is a need to identify new cardiokines...
2.
Kokkonen P, Beier A, Mazurenko S, Damborsky J, Bednar D, Prokop Z
RSC Chem Biol
. 2021 Aug;
2(2):645-655.
PMID: 34458806
Substrate inhibition is the most common deviation from Michaelis-Menten kinetics, occurring in approximately 25% of known enzymes. It is generally attributed to the formation of an unproductive enzyme-substrate complex after...
3.
Laham-Karam N, Pinto G, Poso A, Kokkonen P
Front Chem
. 2020 May;
8:276.
PMID: 32373584
Transcription and translation are fundamental cellular processes that govern the protein production of cells. These processes are generally up regulated in cancer cells, to maintain the enhanced metabolism and proliferative...
4.
Kokkonen P, Slanska M, Dockalova V, Pinto G, Sanchez-Carnerero E, Damborsky J, et al.
Comput Struct Biotechnol J
. 2020 Apr;
18:805-813.
PMID: 32308927
Transport of ligands between bulk solvent and the buried active sites is a critical event in the catalytic cycle of many enzymes. The rational design of transport pathways is far...
5.
Stourac J, Vavra O, Kokkonen P, Filipovic J, Pinto G, Brezovsky J, et al.
Nucleic Acids Res
. 2019 May;
47(W1):W414-W422.
PMID: 31114897
Caver Web 1.0 is a web server for comprehensive analysis of protein tunnels and channels, and study of the ligands' transport through these transport pathways. Caver Web is the first...
6.
Kokkonen P, Bednar D, Pinto G, Prokop Z, Damborsky J
Biotechnol Adv
. 2019 Apr;
37(6):107386.
PMID: 31026496
Enzymes are efficient and specific catalysts for many essential reactions in biotechnological and pharmaceutical industries. Many times, the natural enzymes do not display the catalytic efficiency, stability or specificity required...
7.
Kokkonen P, Sykora J, Prokop Z, Ghose A, Bednar D, Amaro M, et al.
J Am Chem Soc
. 2018 Dec;
140(51):17999-18008.
PMID: 30501200
Enzyme engineering tends to focus on the design of active sites for the chemical steps, while the physical steps of the catalytic cycle are often overlooked. Tight binding of a...
8.
Kokkonen P, Bednar D, Dockalova V, Prokop Z, Damborsky J
J Biol Chem
. 2018 Jun;
293(29):11505-11512.
PMID: 29858243
Haloalkane dehalogenases catalyze the hydrolysis of halogen-carbon bonds in organic halogenated compounds and as such are of great utility as biocatalysts. The crystal structures of the haloalkane dehalogenase DhlA from...
9.
Jurcik A, Bednar D, Byska J, Marques S, Furmanova K, Daniel L, et al.
Bioinformatics
. 2018 May;
34(20):3586-3588.
PMID: 29741570
Motivation: Studying the transport paths of ligands, solvents, or ions in transmembrane proteins and proteins with buried binding sites is fundamental to the understanding of their biological function. A detailed...
10.
Kokkonen P, Kokkola T, Suuronen T, Poso A, Jarho E, Lahtela-Kakkonen M
Eur J Pharm Sci
. 2015 May;
76:27-32.
PMID: 25936698
Sirtuins (SIRT1-SIRT7) are NAD dependent deacetylases and intriguing drug targets in for example neurodegenerative diseases and cancer. Virtual screening has been shown to be a fast and efficient method of...