Minna Rahnasto-Rilla
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Explore the profile of Minna Rahnasto-Rilla including associated specialties, affiliations and a list of published articles.
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25
Citations
278
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Recent Articles
1.
Rahnasto-Rilla M, Puumalainen T, Karttunen V, Adla S, Lahtela-Kakkonen M
Bioorg Med Chem
. 2024 Sep;
112:117884.
PMID: 39226716
Small molecule inhibitors targeting the bromodomain and extra-terminal domain (BET) family proteins have emerged as a promising class of anti-cancer drugs. Nevertheless, the clinical advancement of these agents has been...
2.
Sallomy C, Awolade P, Rahnasto-Rilla M, Hamalainen M, Nousiainen L, Johansson N, et al.
ACS Med Chem Lett
. 2024 Aug;
15(8):1221-1226.
PMID: 39140042
Transient receptor potential ankyrin 1 (TRPA1) protein plays an important role in the inflammatory response, and it has been associated with different pain conditions and pain-related diseases, making TRPA1 a...
3.
Djokovic N, Rahnasto-Rilla M, Lougiakis N, Lahtela-Kakkonen M, Nikolic K
Pharmaceuticals (Basel)
. 2023 Jan;
16(1).
PMID: 36678624
A growing body of preclinical evidence recognized selective sirtuin 2 (SIRT2) inhibitors as novel therapeutics for treatment of age-related diseases. However, none of the SIRT2 inhibitors have reached clinical trials...
4.
Djokovic N, Ruzic D, Rahnasto-Rilla M, Srdic-Rajic T, Lahtela-Kakkonen M, Nikolic K
J Chem Inf Model
. 2022 Apr;
62(10):2571-2585.
PMID: 35467856
Considerations of binding pocket dynamics are one of the crucial aspects of the rational design of binders. Identification of alternative conformational states or cryptic subpockets could lead to the discovery...
5.
Jarvenpaa J, Rahnasto-Rilla M, Lahtela-Kakkonen M, Kublbeck J
Biomed Pharmacother
. 2022 Jan;
147:112652.
PMID: 35065514
Alterations in epigenetic marking, due to changes in expression or activity of epigenetic regulators, may affect cancer development and progression and thus, targeting epigenetic regulators provides potential avenues for cancer...
6.
Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells
Tenhunen J, Kucera T, Huovinen M, Kublbeck J, Bisenieks E, Vigante B, et al.
Biomed Pharmacother
. 2021 Mar;
138:111452.
PMID: 33684691
Sirtuin 6 (SIRT6), a member of sirtuin family (SIRT1-7), regulates a variety of cellular processes involved in aging, metabolism, and cancer. Dysregulation of SIRT6 is widely observed in different breast...
7.
Rahnasto-Rilla M, Jarvenpaa J, Huovinen M, Schroderus A, Ihantola E, Kublbeck J, et al.
Biomed Pharmacother
. 2020 Sep;
131:110701.
PMID: 32905943
Sirtuin 6 (SIRT6), a member of sirtuin family (SIRT1-7), regulates distinct cellular functions; genome stability, DNA repair, and inflammation related diseases. Recently, we demonstrated that anthocyanidins in berries induce the...
8.
Tenhunen J, Kokkola T, Huovinen M, Rahnasto-Rilla M, Lahtela-Kakkonen M
Gene
. 2020 Mar;
741:144558.
PMID: 32165310
The epigenetic regulation of gene expression is controlled by various processes, of which one is histone acetylation. Many proteins control gene expression via histone acetylation. Those proteins include sirtuins (SIRTs)...
9.
Giantin M, Rahnasto-Rilla M, Tolosi R, Lucatello L, Pauletto M, Guerra G, et al.
Sci Rep
. 2019 Dec;
9(1):19672.
PMID: 31873175
Cytochrome P450 3A is the most important CYP subfamily in humans, and CYP3A4/CYP3A5 genetic variants contribute to inter-individual variability in drug metabolism. However, no information is available for bovine CYP3A...
10.
Heger V, Tyni J, Hunyadi A, Horakova L, Lahtela-Kakkonen M, Rahnasto-Rilla M
Biomed Pharmacother
. 2019 Mar;
111:1326-1333.
PMID: 30841446
Polyphenols synthesized by plants and fungi have various pharmacological effects. The ability of polyphenols to modulate sirtuins has gained considerable interest due to the role of sirtuins in aging, insulin...