Tiina Suuronen
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Explore the profile of Tiina Suuronen including associated specialties, affiliations and a list of published articles.
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43
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2106
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Recent Articles
1.
Kokkola T, Suuronen T, Pesonen M, Filippakopoulos P, Salminen A, Jarho E, et al.
Chembiochem
. 2015 Jul;
16(14):1997-2001.
PMID: 26212199
Control of histone acetylation is a part of the epigenetic mechanism that regulates gene expression and chromatin architecture. The members of the bromodomain and extra terminal domain (BET) protein family...
2.
Kokkonen P, Kokkola T, Suuronen T, Poso A, Jarho E, Lahtela-Kakkonen M
Eur J Pharm Sci
. 2015 May;
76:27-32.
PMID: 25936698
Sirtuins (SIRT1-SIRT7) are NAD dependent deacetylases and intriguing drug targets in for example neurodegenerative diseases and cancer. Virtual screening has been shown to be a fast and efficient method of...
3.
Kokkonen P, Mellini P, Nyrhila O, Rahnasto-Rilla M, Suuronen T, Kiviranta P, et al.
Eur J Pharm Sci
. 2014 Apr;
59:12-9.
PMID: 24747578
Sirtuin 1 (SIRT1) is the most studied human sirtuin and it catalyzes the deacetylation reaction of acetylated lysine residues of its target proteins, for example histones. It is a promising...
4.
Kokkola T, Suuronen T, Molnar F, Maatta J, Salminen A, Jarho E, et al.
FEBS Lett
. 2014 Apr;
588(9):1523-8.
PMID: 24681097
The modulation of protein deacetylase SIRT1 has a vast therapeutic potential in treatment of several aging-associated diseases. Active regulator of SIRT1 (AROS) is a small endogenous protein which was originally...
5.
Mellini P, Kokkola T, Suuronen T, Salo H, Tolvanen L, Mai A, et al.
J Med Chem
. 2013 Aug;
56(17):6681-95.
PMID: 23927550
In the past few years sirtuins have gained growing attention for their involvement in many biological processes such as cellular metabolism, apoptosis, aging and inflammation. In this contribution, we report...
6.
Kauppinen A, Suuronen T, Ojala J, Kaarniranta K, Salminen A
Cell Signal
. 2013 Jun;
25(10):1939-48.
PMID: 23770291
Recent studies have indicated that the regulation of innate immunity and energy metabolism are connected together through an antagonistic crosstalk between NF-κB and SIRT1 signaling pathways. NF-κB signaling has a...
7.
Friden-Saxin M, Seifert T, Ryden Landergren M, Suuronen T, Lahtela-Kakkonen M, Jarho E, et al.
J Med Chem
. 2012 Jul;
55(16):7104-13.
PMID: 22746324
A series of substituted chromone/chroman-4-one derivatives has been synthesized and evaluated as novel inhibitors of SIRT2, an enzyme involved in aging-related diseases, e.g., neurodegenerative disorders. The analogues were efficiently synthesized...
8.
Kauppinen A, Niskanen H, Suuronen T, Kinnunen K, Salminen A, Kaarniranta K
Immunol Lett
. 2012 Jun;
147(1-2):29-33.
PMID: 22698681
Oxidative stress and inflammation are known to be associated with age-related macular degeneration (AMD). Retinal pigment epithelial (RPE) cells play the principal role in the immune defense of macula, and...
9.
Huhtiniemi T, Salo H, Suuronen T, Poso A, Salminen A, Leppanen J, et al.
J Med Chem
. 2011 Sep;
54(19):6456-68.
PMID: 21895016
The lack of substrate-bound crystal structures of SIRT1 and SIRT2 complicates the drug design for these targets. In this work, we aim to study whether SIRT3 could serve as a...
10.
Huhtiniemi T, Suuronen T, Lahtela-Kakkonen M, Bruijn T, Jaaskelainen S, Poso A, et al.
Bioorg Med Chem
. 2010 Jul;
18(15):5616-25.
PMID: 20630764
Sirtuins catalyze the NAD(+) dependent deacetylation of N(epsilon)-acetyl lysine residues to nicotinamide, O'-acetyl-ADP-ribose (OAADPR) and N(epsilon)-deacetylated lysine. Here, an easy-to-synthesize Ac-Ala-Lys-Ala sequence has been used as a probe for the...