Efthymia Papalexi
Overview
Explore the profile of Efthymia Papalexi including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
22
Citations
19649
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Jiang L, Dalgarno C, Papalexi E, Mascio I, Wessels H, Yun H, et al.
Nat Cell Biol
. 2025 Feb;
27(3):505-517.
PMID: 40011560
Recent advancements in functional genomics have provided an unprecedented ability to measure diverse molecular modalities, but predicting causal regulatory relationships from observational data remains challenging. Here, we leverage pooled genetic...
2.
Wessels H, Mendez-Mancilla A, Hao Y, Papalexi E, Mauck 3rd W, Lu L, et al.
Nat Methods
. 2022 Dec;
20(1):86-94.
PMID: 36550277
Pooled CRISPR screens coupled with single-cell RNA-sequencing have enabled systematic interrogation of gene function and regulatory networks. Here, we introduce Cas13 RNA Perturb-seq (CaRPool-seq), which leverages the RNA-targeting CRISPR-Cas13d system...
3.
Mimitou E, Lareau C, Chen K, Zorzetto-Fernandes A, Hao Y, Takeshima Y, et al.
Nat Biotechnol
. 2021 Jun;
39(10):1246-1258.
PMID: 34083792
Recent technological advances have enabled massively parallel chromatin profiling with scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here we present ATAC with select antigen profiling by sequencing (ASAP-seq),...
4.
Hao Y, Hao S, Andersen-Nissen E, Mauck 3rd W, Zheng S, Butler A, et al.
Cell
. 2021 Jun;
184(13):3573-3587.e29.
PMID: 34062119
The simultaneous measurement of multiple modalities represents an exciting frontier for single-cell genomics and necessitates computational methods that can define cellular states based on multimodal data. Here, we introduce "weighted-nearest...
5.
Kaufmann K, Zeng A, Coyaud E, Garcia-Prat L, Papalexi E, Murison A, et al.
Nat Immunol
. 2021 May;
22(6):723-734.
PMID: 33958784
Continuous supply of immune cells throughout life relies on the delicate balance in the hematopoietic stem cell (HSC) pool between long-term maintenance and meeting the demands of both normal blood...
6.
Papalexi E, Mimitou E, Butler A, Foster S, Bracken B, Mauck 3rd W, et al.
Nat Genet
. 2021 Mar;
53(3):322-331.
PMID: 33649593
The expression of inhibitory immune checkpoint molecules, such as programmed death-ligand (PD-L)1, is frequently observed in human cancers and can lead to the suppression of T cell-mediated immune responses. Here,...
7.
Stuart T, Butler A, Hoffman P, Hafemeister C, Papalexi E, Mauck 3rd W, et al.
Cell
. 2019 Jun;
177(7):1888-1902.e21.
PMID: 31178118
Single-cell transcriptomics has transformed our ability to characterize cell states, but deep biological understanding requires more than a taxonomic listing of clusters. As new methods arise to measure distinct cellular...
8.
Mimitou E, Cheng A, Montalbano A, Hao S, Stoeckius M, Legut M, et al.
Nat Methods
. 2019 Apr;
16(5):409-412.
PMID: 31011186
Multimodal single-cell assays provide high-resolution snapshots of complex cell populations, but are mostly limited to transcriptome plus an additional modality. Here, we describe expanded CRISPR-compatible cellular indexing of transcriptomes and...
9.
Upadhaya S, Sawai C, Papalexi E, Rashidfarrokhi A, Jang G, Chattopadhyay P, et al.
J Exp Med
. 2018 Oct;
215(11):2815-2832.
PMID: 30291161
Adult hematopoiesis has been studied in terms of progenitor differentiation potentials, whereas its kinetics in vivo is poorly understood. We combined inducible lineage tracing of endogenous adult hematopoietic stem cells...
10.
McKenney A, Lau A, Hanasoge Somasundara A, Spitzer B, Intlekofer A, Ahn J, et al.
J Clin Invest
. 2018 Sep;
128(10):4743.
PMID: 30222137
No abstract available.